Download full-text PDF |
Source |
|---|---|
| http://dx.doi.org/10.1007/s00411-009-0263-7 | DOI Listing |
Publication Analysis
Top Keywords
Similar Publications
Radioresistance and radiosensitivity: a biophysical approach on bacterial cells robustness.
Theory Biosci
February 2023
Institute of Biomedical Sciences, University of Sao Paulo, São Paulo, Brazil.
The study of radiosensitivity and radioresistance of organisms exposed to ionizing radiation has acquired additional relevance since a new bio-concept, coined as The primacy of Proteome over Genome, was proposed and demonstrated elsewhere a few years ago. According to that finding, genome integrity would require an actively functioning Proteome. However, when exposure to radiation takes place, Reactive Oxygen Species (ROS) from water radiolysis induce protein carbonylation (PC), an irreversible oxidative Proteome damage.
View Article and Find Full Text PDFApplication of radiation omics in the development of adverse outcome pathway networks: an example of radiation-induced cardiovascular disease.
Int J Radiat Biol
November 2022
Biology and Environmental Chemistry Division, Sustainable System Research Laboratory, Central Research Institute of Electric Power Industry (CRIEPI), Komae, Japan.
Background: Epidemiological studies have indicated that exposure of the heart to doses of ionizing radiation as low as 0.5 Gy increases the risk of cardiac morbidity and mortality with a latency period of decades. The damaging effects of radiation to myocardial and endothelial structures and functions have been confirmed radiobiologically at high dose, but much less are known at low dose.
View Article and Find Full Text PDFConspicuity of prostate cancer on multiparametric magnetic resonance imaging: A cross-disciplinary translational hypothesis.
FASEB J
November 2020
UCL Division of Surgery & Interventional Science, University College London, London, UK.
Pre-biopsy multiparametric magnetic resonance imaging (mpMRI) has transformed the risk stratification and diagnostic approach for suspected prostate cancer. The majority of clinically significant prostate cancers are visible on pre-biopsy mpMRI, however, there are a subset of significant tumors that are not detected by mpMRI. The radiobiological mechanisms underpinning mpMRI-visibility and invisibility of these cancers remain uncertain.
View Article and Find Full Text PDF[Predictive assays for responses of tumors and normal tissues in radiation oncology].
Cancer Radiother
October 2019
IRCM, institut de recherche en cancérologie de Montpellier, inserm U1194, univ Montpellier, Avenue des Apothicaires, 34298 Montpellier cedex 05, France; Fédération universitaire d'oncologie radiothérapie, icm, institut régional du cancer Montpellier, Rue croix verte, 34298 Montpellier cedex 05, France; Fédération universitaire d'oncologie radiothérapie, institut de cancérologie du Gard, CHU de Nîmes, Rue Henri Pujol, 30000 Nîmes, France. Electronic address:
The impact of curative radiotherapy depends mainly on the total dose delivered homogenously in the target volume. Tumor sensitivity to radiotherapy may be particularly inconstant depending on location, histology, somatic genetic parameters and the capacity of the immune system to infiltrate the tumor. In addition, the dose delivered to the surrounding healthy tissues may reduce the therapeutic ratio of many radiation treatments.
View Article and Find Full Text PDFAdipocyte Secretome Increases Radioresistance of Malignant Melanocytes by Improving Cell Survival and Decreasing Oxidative Status.
Radiat Res
May 2017
a Department of Biochemistry, Faculty of Medicine, University of Porto, Portugal.
Radiotherapy is a treatment option for the majority of malignancies. However, because melanoma is known to be radioresistant, the use of ionizing radiation as an adjuvant therapy in cutaneous melanoma patients is ineffective. Obesity has now been recognized as a risk factor for melanoma.
View Article and Find Full Text PDFWant AI Summaries of new PubMed Abstracts delivered to your In-box?
Enter search terms and have AI summaries delivered each week - change queries or unsubscribe any time!