Enteroviruses cause a wide spectrum of clinical manifestations in neonates, from asymptomatic infection to severe and fulminant, sometimes fatal disease. A septic disease is the clinical manifestation of one fourth of the cases in neonates, with multiorganic affection. Hepatitis and coagulopathy are related to bad prognosis, generally associated to catastrophic hemorrhages. In those cases, an aggressive support therapy and correct administration of platelet and clotting factor replacement is necessary. The liver, in survivors, frequently has sufficient regenerative capacity to allow normalization of hepatic function and adequate growth of the child. We present the case of a newborn who developed hepatitis and coagulopathy secondary to an enteroviral infection, with total recovery and absence of hemorrhagic complication. Her mother had a febrile syndrome 24 hours ante partum.
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http://dx.doi.org/10.1590/S0325-00752009000600014 | DOI Listing |
Trop Doct
January 2025
Consultant Intensivist, Department of Intensive Care, Yashoda Hospitals, Somajiguda, Hyderabad, Telangana, India.
Dengue infection is emerging as one of the most common tropical diseases globally. It manifests in varying severity from asymptomatic to the most severe forms of the disease, characterized by coagulopathy, increased vascular fragility, and permeability (dengue haemorrhagic fever) that may progress to hypovolaemic shock (dengue shock syndrome). For atypical manifestations, a new terminology known as expanded dengue syndrome (EDS) was introduced.
View Article and Find Full Text PDFJ Clin Med
December 2024
San Camillo Forlanini Hospital, Circonvallazione Gianicolense 87, 00186 Rome, Italy.
: Significant intraoperative and postoperative blood loss are rare but possibly life-threatening complications after lung resection surgery either during open or minimally invasive procedures. Microporous Polysaccharide Haemospheres (ARISTA™AH) have demonstrated time-efficient haemostasis, lower postoperative blood volumes and a lower blood transfusion requirement, without any identified adverse events across other specialities. The primary aim of our study was to evaluate the impact of ARISTA™AH on short-term postoperative outcomes in thoracic surgery.
View Article and Find Full Text PDFBMJ Case Rep
January 2025
Accident and Emergency, Birmingham Heartlands Hospital, Birmingham, UK.
Heat stroke is characterised by hyperthermia and acute encephalopathy. We describe a rare case of classical heat stroke secondary to prolonged sauna use with multiorgan sequelae including seizures, liver injury, kidney injury, disseminated intravascular coagulation, rhabdomyolysis and type 2 myocardial infarction. The patient was treated with external cooling, intravenous fluid therapy and blood products, and made a full recovery without need for advanced organ support.
View Article and Find Full Text PDFBiomedicines
December 2024
Department of Surgery, Sepsis and Critical Illness Research Center, College of Medicine, University of Florida, 1600 SW Archer Road Box 100108, Gainesville, FL 32610, USA.
Hemorrhagic shock is caused by rapid loss of a significant blood volume, which leads to insufficient blood flow and oxygen delivery to organs and tissues, resulting in severe physiological derangements, organ failure, and death. Physiologic derangements after hemorrhage are due in a large part to the body's strong inflammatory response, which leads to severe immune dysfunction, and secondary complications such as chronic immunosuppression, increased susceptibility to infection, coagulopathy, multiple organ failure, and unregulated inflammation. Immediate management of hemorrhagic shock includes timely control of the source of bleeding, restoring intravascular volume, preferably with whole blood, and prevention of ischemia and organ failure by optimizing tissue oxygenation.
View Article and Find Full Text PDFBiomedicines
November 2024
Brain Trauma Neuroprotection, Walter Reed Army Institute of Research, Silver Spring, MD 20910, USA.
Traumatic brain injury (TBI) is a global public health concern. It remains one of the leading causes of morbidity and mortality. TBI pathology involves complex secondary injury cascades that are associated with cellular and molecular dysfunction, including oxidative stress, coagulopathy, neuroinflammation, neurodegeneration, neurotoxicity, and blood-brain barrier (BBB) dysfunction, among others.
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