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Proteomic Analysis of Single Hairs.
Methods Mol Biol
December 2024
University of California - Davis, Department of Environmental Toxicology, Davis, CA, USA.
Hair is a ubiquitous and robust mammalian tissue with biological, clinical, forensic, social, and economic significance. The hair shaft proteome reflects both structural proteins, dominated by cuticular intermediate filament keratins and associated proteins, and proteins involved in the final cellular processes of terminally differentiating corneocytes prior to cornification. These distinct biological processes involve cell maintenance, biosynthesis, senescence, and xenobiotic response.
View Article and Find Full Text PDFAction Mechanisms of Exosomes Derived from GD3/GD2-Positive Glioma Cells in the Regulation of Phenotypes and Intracellular Signaling: Roles of Integrins.
Int J Mol Sci
November 2024
Department of Biomedical Sciences, Chubu University, Matsumoto 1200, Kasugai 487-8501, Aichi, Japan.
Extracellular vesicles (EVs) play important roles in intercellular communication in various biological events. In particular, EVs released from cancer cells have attracted special attention. Although it has been reported that cancer-associated glycosphingolipids play important roles in the enhancement of malignant properties of cancer cells, the presence, behavior, and roles of glycosphingolipids in EVs have not been elucidated.
View Article and Find Full Text PDFMortality-associated plasma proteome dynamics in a prospective multicentre sepsis cohort.
EBioMedicine
December 2024
Klinik für Anästhesiologie, Intensivmedizin und Schmerztherapie, Universitätsklinikum Knappschaftskrankenhaus Bochum, Bochum, Germany; Medizinisches Proteom-Center, Medical Faculty, Ruhr University Bochum, Bochum, Germany. Electronic address:
Article Synopsis
- * A study of 363 sepsis patients in Germany analyzed plasma samples on days 1 and 4, identifying 87 and 95 significantly different proteins related to survival outcomes, using statistical methods and machine learning for analysis.
- * The research highlighted shifts in protein networks linked to blood coagulation and immune responses over time, suggesting potential new therapeutic targets and a focus on the innate immune system in treating sepsis.
The temporal dynamics of proteins in aged skin wound healing and comparison to gene expression.
J Invest Dermatol
December 2024
Dermatology and Venereology Division, Department of Medicine (Solna), Karolinska Institutet, Stockholm, Sweden; Dermato-Venereology Clinic, Karolinska University Hospital, Stockholm, Sweden. Electronic address:
Neuroendocrine regulatory network underlying physiological shifts between reproduction and aestivation of sea cucumber Apostichopus japonicus: Insights from transcriptome analysis.
Comp Biochem Physiol Part D Genomics Proteomics
December 2024
National Engineering Laboratory of Marine Germplasm Resources Exploration and Utilization, Marine Science and Technology College, Zhejiang Ocean University, Zhoushan, Zhejiang 316022, People's Republic of China. Electronic address:
The sea cucumber Apostichopus japonicus is an economically significant marine species in China, with numerous studies focusing on its diverse physiological processes, including seasonal reproduction and aestivation. The neuroendocrine system plays a critical role in regulating these physiological transitions. In this study, we utilized transcriptomic techniques and bioinformatics tools to identify key functional genes in the nerve ring of A.
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