It has been shown in a previous study that brown coal-derived potassium humate is safe and effective in suppressing contact hypersensitivity in rats. In this study the efficacy of potassium humate on other types of inflammation was determined. Preparative TLC followed by mass spectroscopy was used in an attempt to fingerprint the product. The effects of potassium humate, at an oral dose of 60 mg/kg bodyweight, on a delayed type hypersensitivity reaction, a carrageenan-induced inflammation model and an allogeneic graft-versus-host reaction (GVHR) in rats were investigated. Paw oedema was used as a measure of inflammation. It was found that potassium humate had no effect on the delayed type hypersensitivity reaction but significantly inhibited the increase in paw volume of the carrageenan-induced oedema in rats which compared favourably with indomethacin treatment. Furthermore, potassium humate inhibited the GVHR induced in normal and cyclophosphamide-treated immune-incompetent rats. The identification of a naturally occurring compound that is safe and effective in reducing different types of inflammation merits further evaluation in clinical trials.
Download full-text PDF |
Source |
|---|---|
| http://dx.doi.org/10.1007/s10787-009-0026-8 | DOI Listing |
Publication Analysis
Top Keywords
Similar Publications
The input of organic fertilizer can improve soil physicochemical properties and increase cotton yield in southern Xinjiang.
Front Plant Sci
January 2025
College of Resources and Environment, Xinjiang Agricultural University, Urumqi, China.
In this study, the improvement effect of different organic substances on compacted cohesive soil in southern Xinjiang was discussed, with emphasis on the influence of different organic substances on soil chemical properties and microorganisms, so as to determine the best carbon source input and provide theoretical support for the rational utilization of organic materials in southern Xinjiang. Field experiments were conducted to evaluate the effects of farm fertilizer, biochar, commercial organic fertilizer, microbial fertilizer and mineral potassium humate on physical and chemical properties of viscous soil, agronomic properties and yield of cotton, with three gradients for each organic fertilizer. The results showed that: (1) all organic fertilizers improved soil structure, among which farm fertilizer significantly reduced soil bulk density and salinity, increased soil organic matter, total nitrogen and available nutrients, and thus increased cotton height, stem diameter and yield.
View Article and Find Full Text PDFPrepartum Dietary Supplementation of Potassium Humate Improves Postpartum Lactation Performance, Metabolic Profile of Multiparous Cows, and Immune Response of Their Calves.
Animals (Basel)
January 2025
Department of Animal Nutrition, Faculty of Veterinary Medicine, Afyon Kocatepe University, ANS Campus, Afyonkarahisar 03200, Türkiye.
This research was carried out to determine the effects of potassium humate on the lactation performance and metabolic parameters of dairy cows during the transition period. Potassium humate was added to the concentrate feed at the following levels: (a) control (0%), (b) 0.5%, (c) 1%, (d) 1.
View Article and Find Full Text PDFCharacterization of fluoranthene degradation by the novel isolated Pseudomonas xizangensis S4 and its application potential immobilized in potassium humate-modified biochar.
Bioresour Technol
January 2025
Key Laboratory of Resource Biology and Biotechnology in Western China, Ministry of Education, Provincial Key Laboratory of Biotechnology, College of Life Sciences, Northwest University, 229 Taibai North Road, Xi'an, Shaanxi 710069, China. Electronic address:
Enhanced microbial remediation represents a promising technique for the removal of polycyclic aromatic hydrocarbons (PAHs). However, high-efficiency remediation agents remain limited, including microbial resources and remediation materials. In this study, a novel strain of Pseudomonas xizangensis S4 was isolated from plateau lake sediment, exhibiting a fluoranthene degradation rate of 41.
View Article and Find Full Text PDFCo-application of organic amendments and natural biostimulants on plants enhances wheat production and defense system under salt-alkali stress.
Sci Rep
November 2024
Deprtment of Biology, College of Science, United Arab Emirates University, Al Ain, 15551, UAE.
Article Synopsis
- * The study found that using vermicompost with bio-stimulants, particularly moringa leaf extract (MLE), greatly enhanced wheat growth, yield, and nutrient absorption, outperforming other organic options.
- * The combination of vermicompost and MLE increased plant height, leaf area, and photosynthesis, leading to significant rises in both straw (64%) and grain (27%) yields compared to control groups, highlighting a promising sustainable approach for farmers.
The addition of humic acid into soil contaminated with microplastics enhanced the growth of black gram (Vigna mungo L. Hepper) and modified the rhizosphere microbial community.
Environ Sci Pollut Res Int
November 2024
Centre for Environmental Studies, Department of Civil Engineering, College of Engineering Guindy, Anna University, Chennai, Tamil Nadu, 600 025, India.
Microplastics have polluted agricultural soils, posing a substantial risk to crop productivity. Moreover, the presence of microplastic pollution has caused a disturbance in the composition of the microbial community in the soil surrounding plant roots, therefore impacting the growth of beneficial bacteria. A study was conducted to examine if humic acid (HA) can counteract the harmful effects of microplastics (MPs) on the growth of black gram crops and the composition of the rhizosphere soil microbial community, to reduce the negative impacts of microplastics on these microorganisms and crops.
View Article and Find Full Text PDFWant AI Summaries of new PubMed Abstracts delivered to your In-box?
Enter search terms and have AI summaries delivered each week - change queries or unsubscribe any time!