A simple rapid spectrophotometric method has been developed for estimation of cefuroxime axetil from bulk drug and tablet dosage form by using 1-nitroso-2-napthol and sodium hydroxide. The method is based on the formation of yellow-orange coloured complex of drug with 1-nitroso-2-napthol having absorbance maxima at 424 nm. The Beer's law is obeyed in the concentration range of 10-50 mug/ml of the drug but more precisely it obeys in the range of 10- 30 mug/ml. The slope and intercept values are 0.0101 and 0.0838, respectively. Results of analysis of this method were validated statistically and by recovery studies. The method is applied to the marketed tablet formulation. Result of analysis of tablet formulation given as percentage of label claim +/-standard deviation is 99.17+/-1.57. The precision and accuracy was examined by performing recovery studies and was found to be 99.50+/-1.82. Sandell's correlation coefficient is calculated as 0.4434. The developed method is simple, sensitive and reproducible and can be used for routine analysis of cefuroxime axetil from bulk and tablet dosage form.
Download full-text PDF |
Source |
|---|---|
| http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2792481 | PMC |
| http://dx.doi.org/10.4103/0250-474X.41468 | DOI Listing |
Publication Analysis
Top Keywords
Similar Publications
Long-term forecast for antibacterial drug consumption in Germany using ARIMA models.
Naunyn Schmiedebergs Arch Pharmacol
January 2025
Hannover Medical School, Institute of Pharmacology, D-30625, Hannover, Germany.
Article Synopsis
- This study forecasts the consumption of the top ten antibacterial drugs in Germany until 2040, using historical prescription data and ARIMA models.
- The best model for forecasting is a simple random walk with drift (ARIMA(0,1,0)), while short-term predictions show minimal variation among complex models.
- Predictions indicate rising prescriptions for some drugs like amoxicillin, but declines for others, emphasizing the need for proactive healthcare planning to address potential shortages.
Antibiotic resistance in community-acquired urinary tract infections. Did the COVID-19 pandemic cause a change?
J Infect Dev Ctries
September 2024
Division of Allergy and Immunology, Department of Pediatrics; School of Medicine, University of Kyrenia, Kyrenia, Cyprus.
Article Synopsis
- The study evaluated antimicrobial resistance rates in urine cultures before and during the COVID-19 pandemic, analyzing data from 897 patients over six years.
- E. coli and K. pneumoniae were the primary bacteria identified, with increased resistance rates for antibiotics like cefixime and ceftriaxone during the pandemic.
- Factors such as male gender and ESBL positivity were linked to higher resistance rates, indicating a notable increase in antibiotic resistance among uropathogens during this period.
Synthesis, Characterization, Bioavailability and Antimicrobial Studies of Cefuroxime-Based Organic Salts and Ionic Liquids.
Pharmaceutics
October 2024
LAQV-REQUIMTE, Department of Chemistry, NOVA School of Science and Technology, NOVA University of Lisbon, 2819-516 Caparica, Portugal.
Low oral bioavailability is a common feature in most drugs, including antibiotics, due to low solubility in physiological media and inadequate cell permeability, which may limit their efficacy or restrict their administration in a clinical setting. Cefuroxime is usually administered in its prodrug form, cefuroxime axetil. However, its preparation requires further reaction steps and additional metabolic pathways to be converted into its active form.
View Article and Find Full Text PDFDevelopment of bacterial resistance in Germany from 2008 to 2022 - major culprit pathogens, antibacterial drugs, and prescribing practices.
Naunyn Schmiedebergs Arch Pharmacol
October 2024
Institute of Pharmacology, Hannover Medical School, Hannover, D-30625, Germany.
Rising bacterial resistance is a global threat, causing rising financial burdens on healthcare systems and endangering effective treatment of bacterial infections. To ensure the efficacy of antibacterial drugs, it is essential to identify the most dangerous pathogens and vulnerable antibacterial drugs. Previous research by our group suggested irrational outpatient prescribing practices in Germany, supporting a growing bacterial resistance.
View Article and Find Full Text PDFDaily defined dose-costs have a stronger influence on antibacterial drug prescriptions in Germany than bacterial resistance: economic factors are more important than scientific evidence.
Naunyn Schmiedebergs Arch Pharmacol
September 2024
Institute of Pharmacology, Hannover Medical School, 30625, Hannover, Germany.
Previous research from our group revealed a strong association between daily defined dose (DDD)-costs and -prescriptions of antibacterial drugs in Germany ( https://pubmed.ncbi.nlm.
View Article and Find Full Text PDFWant AI Summaries of new PubMed Abstracts delivered to your In-box?
Enter search terms and have AI summaries delivered each week - change queries or unsubscribe any time!