AI Article Synopsis
- T helper (Th) 17 cells are a recently identified type of T helper cells that play a significant role in autoimmune diseases and immune responses needed for fighting off infections.
- These cells are crucial for defending against extracellular bacteria and fungi but can also lead to negative effects like chronic inflammation and viral persistence under certain conditions.
- The effectiveness of Th17 responses varies based on the type of microorganisms involved and the context of the immune response, balancing protective benefits and potential harmful effects.
Article Abstract
T helper (Th) 17 cells have recently been described as a third subset of T helper cells, and have provided new insights into the mechanisms that are important in the development of autoimmune diseases and the immune responses that are essential for effective antimicrobial host defense. Both protective and harmful effects of Th17 responses during infection have been described. In general, Th17 responses are critical for mucosal and epithelial host defense against extracellular bacteria and fungi. However, recent studies have reported that Th17 responses can also contribute to viral persistence and chronic inflammation associated with parasitic infection. It has become evident that the type of microorganisms and the setting in which they trigger the Th17 response determines the outcome of the delicate balance that exists between Th17 induced protection and immunopathogenesis.
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| http://dx.doi.org/10.5483/bmbrep.2009.42.12.776 | DOI Listing |
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