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Drastic effects on fibril formation of amyloid-beta peptides by the addition of amino acid residue units to the termini. | LitMetric
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Drastic effects on fibril formation of amyloid-beta peptides by the addition of amino acid residue units to the termini.

Yuya Asanomi Yumiko Kobayashi Hiroki Sakai Takuya Masuda Xinjiang Chen Yoshiro Chuman Kohei Uosaki Kazuyasu Sakaguchi

Protein Pept Lett

Laboratory of Biological Chemistry, Department of Chemistry, Faculty of Science, Hokkaido University, N10, W8, Kita-ku, Sapporo 060-0810, Japan.

Published: April 2010

We report that the addition of amino acids to the amyloid peptide dramatically affected the structure and the rate of formation of amyloid fibrils. The attachment of three lysines to Abeta(10-35) gave the formation of remarkably long fibrils, while three glutamates resulted in a faster formation rate of the fibrils.

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http://dx.doi.org/10.2174/092986610790963618DOI Listing

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