Background: CDX2 is a gene involved in the regulation of intestinal cell proliferation/differentiation. It is considered specific for enterocytes and has been used for the diagnosis of primary and metastatic colon adenocarcinoma. The aim of this study was to assess the usefulness of CDX2 in the diagnosis of cutaneous metastatic tumors and extramammary Paget's disease.
Materials And Methods: The immunohistochemical expression of CDX2 was studied in 68 cutaneous metastatic tumors of various origins and 14 specimens of extramammary Paget's disease.
Results: CDX2 expression was found in 3/6 metastases of colon adenocarcinoma, 1/1 metastasis of urothelial carcinoma and 1/2 extramammary Paget's disease.
Conclusion: CDX2 appears to be specific for cutaneous metastases from intestinal and urothelial carcinomas and is a useful diagnostic marker of these tumors. However, its sensitivity is modest, and we advocate its use in conjunction with additional immunohistochemical markers. CDX2 seems useful for the diagnosis of extramammary Paget's disease associated with an underlying colorectal tumor.
Download full-text PDF |
Source |
|---|
Publication Analysis
Top Keywords
Similar Publications
A multicenter study on TROP2 as a potential targeted therapy for extramammary Paget disease in Japan.
Sci Rep
January 2025
Department of Dermatology, Graduate School of Medical Sciences, Kyushu University, 3-1-1 Maidashi, Higashi-ku, Fukuoka, 812-8582, Japan.
Extramammary Paget disease (EMPD) is a rare skin cancer that typically occurs in the anogenital area of older people. Since efficacy of treatments for metastatic or unresectable EMPD remains poor, development of a novel therapeutic approach is strongly desired. However, the lack of EMPD models has hampered investigation of EMPD.
View Article and Find Full Text PDFTopical imiquimod: A miraculous option in extramammary Paget's disease?
Med J Armed Forces India
December 2024
Brig Med, HQ 14 Corps, C/o 56 APO, India.
Extramammary Paget's Disease.
Br J Dermatol
December 2024
Department of Dermatology, The First Hospital of China Medical University, Shenyang, China; Key laboratory of Immunodermatology, Ministry of Health and Education, Shenyang, China.
Triple-negative ectopic breast cancer of the male scrotum: a case report.
Front Oncol
December 2024
Weifang People's Hospital, Shandong Second Medical University, Weifang, Shandong, China.
Male breast cancer represents only 1% of all breast malignancies, with ectopic breast cancer in men being even rarer and highly prone to diagnostic challenges. Extramammary Paget's disease (EMPD), a rare cutaneous tumor with non-specific clinical symptoms, is susceptible to misdiagnosis. This report discusses the case of an older male patient who presented with a scrotal mass, later identified as ectopic breast invasive adenocarcinoma upon pathological examination post-lesion excision.
View Article and Find Full Text PDFWant AI Summaries of new PubMed Abstracts delivered to your In-box?
Enter search terms and have AI summaries delivered each week - change queries or unsubscribe any time!