The earliest diagnosis of diabetes is a mandate to arrest the worldwide epidemic of diabetes. The insulin assay with the oral glucose tolerance provides the earliest diagnosis. The pathology of diabetes occurs in those with normal blood sugars. With earliest diagnosis, the 'diabetes epidemic' can be arrested and then reversed.
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Anatomical Insights: Two Case Reports on Protostylid Variants and Literature Synthesis.
Cureus
November 2024
Public Health Dentistry, Sathyabama Dental College and Hospital, Sathyabama Institute of Science and Technology, Chennai, IND.
Protostylids are an anatomical variant of the paramolar tubercle, which refers to the presence of an additional cusp in the buccal surfaces of maxillary and mandibular bicuspids and molars. This structure, first reported by Dahlberg in 1950, is found in low frequencies and plays a significant role in dental anthropology. This anatomical variant, if present poses a threat to dental caries and periodontal diseases and hence requires early diagnosis and preventive dental care.
View Article and Find Full Text PDFChallenges in Describing Tremor and Dystonia.
Neurology
January 2025
Departments of Neurology, Human Genetics and Pediatrics, Emory University, Atlanta, GA.
Tremor is defined as an oscillatory and rhythmical movement. By contrast, dystonia is defined by sustained or intermittent abnormal postures, repetitive movements, or both. Tremor and dystonia often coexist in the same individual.
View Article and Find Full Text PDF[Characteristics of postmortem changes in the brain].
Sud Med Ekspert
December 2024
National Medical Research Center for Obstetrics, Gynecology and Perinatology named after Academician V.I. Kulakov, Moscow, Russia.
The study aimed to analyze the literature data on postmortem changes in the brain and their use to determine the time since death. The earliest manifestations of brain cell autolysis are detected by electron microscopy (15-20 minutes after death). The longer the postmortem period, the more morphofunctional changes in the brain are revealed by histological, histochemical, and immunohistochemical studies.
View Article and Find Full Text PDFNon-tuberculous Mycobacterial Pulmonary Disease (NTM-PD) is a chronic disease characterised by progressive inflammatory lung damage due to infection by non-tuberculous mycobacteria (NTM). Global prevalence of NTM-PD is generally low but is rising, likely due to a combination of increased surveillance, increasing multimorbidity and improved diagnostic techniques. Most disease is caused by Mycobacterium avium complex species.
View Article and Find Full Text PDFInvestigating phenotypic variability patterns in myotonic dystrophy type 2 in a neuromuscular referral center retrospective cohort.
Neuromuscul Disord
November 2024
Department of Neurology, Massachusetts General Hospital, Harvard Medical School, Boston, MA02114, United States. Electronic address:
We aimed at investigating the presence of patterns that account for the phenotypic variability in a myotonic dystrophy type 2 (DM2) retrospective cohort at the Mass General Brigham Neuromuscular Centers. We collected the presence or absence of 23 clinical variables at symptom onset and diagnosis (n = 67 patients) and follow-up (n = 37 patients). We first identified set/s of variables (factors or cluster/s) representative of the large research data pool at onset by performing factor analyses, then assigned each patient to the cluster for which they had the highest computed total factor score.
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