In this study, restless legs syndrome (RLS) risk factors, RLS-associated behaviors, and the ability to understand and answer an RLS diagnostic interview were investigated. In 23 older adults with early to moderate dementia and nighttime sleep disturbance, the most common risk factors for RLS were a periodic leg movement sleep index > 15 (54.55%), based on polysomnography, and use of selective serotonin reuptake inhibitors (SSRIs) (34.78%). The most common RLS-associated behaviors were repetitious mannerisms (56.52%) and general restlessness (34.78%), according to direct observation from research assistants. Finally, older adults with early to moderate dementia were unable to understand and reliably answer the RLS diagnostic interview. Older persons with mild to moderate dementia and sleep disturbance may require objective diagnostics to identify RLS.

Download full-text PDF

Source
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3745281PMC
http://dx.doi.org/10.1080/15402000903425769DOI Listing

Publication Analysis

Top Keywords

moderate dementia
16
risk factors
12
early moderate
12
sleep disturbance
12
restless legs
8
legs syndrome
8
dementia sleep
8
rls-associated behaviors
8
answer rls
8
rls diagnostic
8

Similar Publications

Mapping the neural substrate of high dual-task gait cost in older adults across the cognitive spectrum.

Brain Struct Funct

January 2025

Department of Medical Biophysics, Schulich School of Medicine & Dentistry, Western University, 1151 Richmond Street, North London, ON, N6A 5C1, Canada.

The dual task cost of gait (DTC) is an accessible and cost-effective test that can help identify individuals with cognitive decline and dementia. However, its neural substrate has not been widely described. This study aims to investigate the neural substrate of the high DTC in older adults across the spectrum of cognitive decline.

View Article and Find Full Text PDF

The Effect of Adherence to a Tai Chi Intervention on Quality of Life of Older People Living With Dementia.

J Aging Phys Act

January 2025

Bournemouth University Clinical Research Unit, Faculty of Health & Social Sciences, Bournemouth University, Poole, United Kingdom.

Background/objectives: Adherence to exercise programs is required to reap their established benefits and to sustain Quality of Life (QoL). This study explored People Living with Dementia's (PLWD) adherence to a Tai Chi exercise program and its effects on their QoL. The study included assessment of factors affecting adherence to a Tai Chi exercise intervention, causes of nonadherence, and effect of adherence on PLWD's QoL.

View Article and Find Full Text PDF

Basic Science and Pathogenesis.

Alzheimers Dement

December 2024

College of Public Health, University of Kentucky, Lexington, KY, USA.

Background: Brain arteriolosclerosis (B-ASC) is a pathologic hallmark characterized by dysmorphic brain arteriolar wall thickening. B-ASC is a common finding at autopsy in aged persons - some degree of B-ASC is seen in >80% of brains beyond age 80 years - and is associated with cognitive impairment. Hypertension and diabetes are widely recognized as risk factors for B-ASC.

View Article and Find Full Text PDF

Background: Sleep dysfunction is commonly seen in Alzheimer's disease (AD) and Progressive Supranuclear Palsy (PSP), potentially worsening these conditions. Investigating early neuropathological changes in human sleep-promoting neurons, which often precede cognitive decline, is crucial for understanding the basis for sleep dysfunction as possible treatments yet remain underexplored. We used postmortem brains of AD and PSP patients to quantify neuronal numbers and tau burden in the intermediate nucleus of the hypothalamus (IntN), VLPO analog, known for its role in sleep maintenance.

View Article and Find Full Text PDF

Background: White matter hyperintensities (WMH) are commonly observed on MRI in Alzheimer's disease (AD), but the molecular pathways underlying their relationships with the ATN biomarkers remain unclear. The aim of this study was to identify genetic variants that may modify the relationship between WMH and the ATN biomarkers.

Method: This genome-wide interaction study (GWIS) included individuals with AD, MCI, and normal cognition from ADNI (n = 1012).

View Article and Find Full Text PDF

Want AI Summaries of new PubMed Abstracts delivered to your In-box?

Enter search terms and have AI summaries delivered each week - change queries or unsubscribe any time!