Severity: Warning
Message: file_get_contents(https://...@pubfacts.com&api_key=b8daa3ad693db53b1410957c26c9a51b4908&a=1): Failed to open stream: HTTP request failed! HTTP/1.1 429 Too Many Requests
Filename: helpers/my_audit_helper.php
Line Number: 176
Backtrace:
File: /var/www/html/application/helpers/my_audit_helper.php
Line: 176
Function: file_get_contents
File: /var/www/html/application/helpers/my_audit_helper.php
Line: 250
Function: simplexml_load_file_from_url
File: /var/www/html/application/helpers/my_audit_helper.php
Line: 1034
Function: getPubMedXML
File: /var/www/html/application/helpers/my_audit_helper.php
Line: 3152
Function: GetPubMedArticleOutput_2016
File: /var/www/html/application/controllers/Detail.php
Line: 575
Function: pubMedSearch_Global
File: /var/www/html/application/controllers/Detail.php
Line: 489
Function: pubMedGetRelatedKeyword
File: /var/www/html/index.php
Line: 316
Function: require_once
Purpose: To examine dark-adapted retinal function in subjects with type 2 diabetes during transient hyperglycemia.
Methods: Twenty-four subjects with type 2 diabetes and minimal diabetic retinopathy were randomized to an oral glucose tolerance test (OGTT) or a fasting regimen. One study eye was kept in the dark-adapted state at all times. Full-field electroretinography (ffERG) and blood glucose measurements were performed at baseline and after 20, 80, 140, and 200 minutes.
Results: Mean capillary glucose had increased 162% from the fasting baseline value when the concentration peaked in the OGTT group after 80 minutes (P < 0.0001). Concomitantly, rod b-wave amplitude had increased by 34% (P = 0.0007), whereas the a- and b-wave amplitudes of the standard combined rod-cone response had increased by 17% (P = 0.0013 and P = 0.0064). The dark-adapted 30-Hz flicker response was unaffected by hyperglycemia. The scotopic ffERG amplitudes rose and fell in phase with the glycemia. Implicit times did not change with the rise and fall in glycemia.
Conclusions: The change in scotopic signaling amplitude in the outer and middle layers of retina in subjects with diabetes was proportional to the change in capillary glucose. Cone amplitude was not influenced by hyperglycemia in this study.
Download full-text PDF |
Source |
---|---|
http://dx.doi.org/10.1167/iovs.09-4891 | DOI Listing |
Enter search terms and have AI summaries delivered each week - change queries or unsubscribe any time!