AI Article Synopsis
- Disease control in Farrer's scallop (Chalmys farreri) relies heavily on understanding its innate immune system, particularly the role of serine proteases, which amplify immune signals.
- Recent research has mostly focused on the sequence and expression of these proteases, but this study is the first to identify their specific chromosomal location using BAC-FISH technique.
- The study identified six SNPs within the serine protease gene, which can aid in developing a genetic linkage map for C. farreri, enhancing future research efforts on its immune response.
Article Abstract
Disease control is a main objective in the culture of Farrer's scallop (Chalmys farreri). Many investigations have focused on the innate immune system of this species. Serine proteases amplify signals in many immune-related pathways and thus play a crucial role in innate immune system. Recently, studies on serine protease in C. farreri were mainly on sequence analysis and expression profile, but no study on gene localization was reported. In this study, a BAC clone (CFB040H03) that contains a serine protease gene of C. farreri was located on the long arms of a pair of homologous chromosomes by BAC-FISH technique. Six SNPs were found inside the serine protease gene using direct sequencing of the PCR products. The chromosomal localization of serine protease gene would provide fundamental support for further research on this gene. The SNPs obtained can be mapped to the genetic linkage map and is helpful to the construction of the integration map of C. farreri.
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| http://dx.doi.org/10.3724/sp.j.1005.2009.01241 | DOI Listing |
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