In this study, the finite element method is employed to calculate SAW characteristics in (100) AlN/diamond based structures with different electrical interfaces; i.e., IDT/ AlN/diamond, AlN/IDT/diamond, IDT/AlN/thin metal film/ diamond, and thin metal film/AlN/IDT/diamond. The effects of Cu and Al electrodes as well as the thickness of electrode on phase velocity, coupling coefficient, and reflectivity of SAWs are illustrated. Propagation characteristics of SAWs in (002) AlN/diamond-based structures are also presented for comparison. Simulation results show that to retain a large reflectivity for the design of RF filters and duplexers, the Cu IDT/(100) AlN/diamond structure possesses the highest phase velocity and largest coupling coefficient at the smallest AlN film thickness- to-wavelength ratio.
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http://dx.doi.org/10.1109/TUFFC.2010.1377 | DOI Listing |
Alzheimers Dement
December 2024
UCL Centre for Medical Image Computing, Department of Computer Science, University College London, London, UK.
Background: Connectome-based models of disease propagation are used to probe mechanisms of pathology spread in neurodegenerative disease. We present our network spreading model toolbox that allows the user to compare model fits across different models and parameters. We apply the toolbox to assess whether local amyloid levels affect production of pathological tau.
View Article and Find Full Text PDFBackground: Neuroinflammation and activation of the immune system can influence Alzheimer's disease (AD) progression. This is mediated by inflammatory molecules, which exacerbate the production of β-amyloid, the propagation of tau pathology, and neuronal loss. By measuring CSF markers of inflammation in a heterogeneous clinical cohort we found that levels of Adenosine Deaminase (ADA) and Matrix-Metaloproteinase-10 (MMP-10) increase in patients with AD.
View Article and Find Full Text PDFAlzheimers Dement
December 2024
Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA, USA.
Background: The structural characteristics of the brain, specifically the decrease of individual gray (or white) matter volumes, provide valuable insights into brain function and cognitive decline, including the development of Alzheimer's disease (AD). In addition, genetic factors can play a significant role in changes in brain volumes, influencing biological activities and interacting in complex ways. In this study, we aim to investigate the relationship between genetic factors, structural brain volume, and the risk of AD.
View Article and Find Full Text PDFAlzheimers Dement
December 2024
The University of Texas Health Science Center at Houston, Houston, TX, USA.
Background: Alzheimer's disease (AD) is an heterogenous disorder characterized by the accumulation of amyloid-beta (Aβ) and tau. One possible explanation for the clinical and pathological variation in AD lies in the presence of distinct conformational strains of Aβ. Numerous studies provide compelling evidence for the existence of such strains as well as their ability to template their conformations in a prion-like manner.
View Article and Find Full Text PDFAlzheimers Dement
December 2024
UCL Centre for Medical Image Computing, Department of Computer Science, University College London, London, United Kingdom.
Background: Connectome-based models of disease propagation are used to probe mechanisms of pathology spread in neurodegenerative disease. We present our network spreading model toolbox that allows the user to compare model fits across different models and parameters. We apply the toolbox to assess whether local amyloid levels affect production of pathological tau.
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