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Endothelial METAP1: Tipping the Angiogenic Scales in Postpartum Preeclampsia.
Circ Res
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Department of Medicine, Division of Clinical Pharmacology; and Division of Cardiovascular Medicine, Vanderbilt University Medical Center, Nashville, TN (M.R.A.).
Machine Learning(s) in gaming disorder through the user-avatar bond: A step towards conceptual and methodological clarity.
J Behav Addict
December 2024
12International Gaming Research Unit, Psychology Dept, Nottingham Trent University, UK.
In response to our study, the commentary by Infanti et al. (2024) raised critical points regarding (i) the conceptualization and utility of the user-avatar bond in addressing gaming disorder (GD) risk, and (ii) the optimization of supervised machine learning techniques applied to assess GD risk. To advance the scientific dialogue and progress in these areas, the present paper aims to: (i) enhance the clarity and understanding of the concepts of the avatar, the user-avatar bond, and the digital phenotype concerning gaming disorder (GD) within the broader field of behavioral addictions, and (ii) comparatively assess how the user-avatar bond (UAB) may predict GD risk, by both removing data augmentation before the data split and by implementing alternative data imbalance treatment approaches in programming.
View Article and Find Full Text PDFEarly Intervention in Patients With Asymptomatic Severe Aortic Stenosis and Myocardial Fibrosis: The EVOLVED Randomized Clinical Trial.
JAMA
January 2025
British Heart Foundation Centre of Research Excellence, University of Edinburgh, Edinburgh, Scotland.
Importance: Development of myocardial fibrosis in patients with aortic stenosis precedes left ventricular decompensation and is associated with an adverse long-term prognosis.
Objective: To investigate whether early valve intervention reduced the incidence of all-cause death or unplanned aortic stenosis-related hospitalization in asymptomatic patients with severe aortic stenosis and myocardial fibrosis.
Design, Setting, And Participants: This prospective, randomized, open-label, masked end point trial was conducted between August 2017 and October 2022 at 24 cardiac centers across the UK and Australia.
Is peer support a tipping point for the opioid use disorder crisis in Appalachia? Research holds the answer.
Harm Reduct J
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East Tennessee State University Addiction Science Center, 2109 West Market Street, Johnson City, TN, 37604, USA.
Background: The present commentary highlights the pressing need for systematic research to assess the implementation and effectiveness of medications for opioid use disorder, used in conjunction with peer recovery support services, to improve treatment outcomes for individuals with opioid use disorder in Central Appalachia. This region, encompassing West Virginia, Eastern Kentucky, Southwest Virginia, East Tennessee, and Western North Carolina, has long grappled with a disproportionate burden of the opioid crisis. Due to a complex interplay of cultural, socioeconomic, medical, and geographic factors, individuals in Central Appalachia face challenges in maintaining treatment and recovery efforts, leading to lower success rates.
View Article and Find Full Text PDFKetones with a twist: Tipping the heart's hat to fat.
Obesity (Silver Spring)
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Departments of Medicine and Nutrition & Exercise Physiology, University of Missouri School of Medicine, Columbia, Missouri, USA.
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