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Scoliosis in adult Type 1 Chiari malformation with syringomyelia patients: from pathogenesis to treatment.
Am J Transl Res
December 2024
Department of Orthopaedics, Beilun District People's Hospital, Beilun Branch of The First Affiliated Hospital, Zhejiang University Ningbo, Zhejiang, China.
The pathogenesis of type I Chiari malformation (CIM) is complex and remains unclear. The theory of posterior cranial fossa incompatibility has gained widespread acceptance in recent years. In the patients with CIM combined with syringomyelia, scoliosis is a common occurrence, with severe cases often leading to complications that necessitate surgical intervention.
View Article and Find Full Text PDFFibromyalgia severity and symptoms are associated with the disorders of gut-brain interaction.
Eur J Pain
January 2025
School of Pharmacy, Faculty of Medicine and Health, The University of Sydney, Camperdown, New South Wales, Australia.
Article Synopsis
- Fibromyalgia is a common disorder characterized by widespread pain, and this study explored its connection with disorders of gut-brain interaction (DGBI) in women, revealing that many had DGBI alongside their fibromyalgia symptoms.
- The research, conducted in New Zealand, included 111 women and found that 93% had at least one DGBI, with many reporting the presence of multiple conditions affecting their pain severity, sleep quality, and overall health.
- The findings highlight the need for further studies to understand the causes of DGBI in women with fibromyalgia, as multiple DGBI were linked to increased pain and other symptoms like migraines and sleep disturbances.
Assessing real-world safety of plecanatide: a pharmacovigilance study based on the FDA adverse event reporting system.
Front Pharmacol
November 2024
The Second Clinical College of Dalian Medical University, Dalian Medical University, Dalian, Liaoning, China.
Article Synopsis
- Plecanatide is a gastro-peptide used to treat chronic constipation and IBS with constipation, and this study aimed to evaluate its long-term safety in real-world scenarios.
- Data from the FDA Adverse Event Reporting System between 2017 and 2024 revealed 861 cases and 2057 adverse event reports, with diarrhea and abdominal issues being common side effects.
- The study suggests that most adverse events occur within the first week of treatment and provides critical safety insights for healthcare providers prescribing plecanatide.
A rare atypical Idiopathic Mesenteric Phlebosclerosis( original text: IMP) characterized by widespread submucosal bulges of small bowel and colon: first report.
Gastrointest Endosc
November 2024
Department of Gastroenterology, Degestive Disease Hospital, Affiliated Hospital of Zunyi Medical University, Zunyi, China. Electronic address:
Systemic capillary leak syndrome.
Nat Rev Dis Primers
November 2024
Division of Nephrology, Departments of Internal Medicine and Pharmacology, University of Texas Southwestern Medical Center, Dallas, TX, USA.
The vascular endothelial barrier maintains intravascular volume and metabolic homeostasis. Although plasma fluids and proteins extravasate continuously from tissue microvasculature (capillaries, post-capillary venules), systemic vascular leakage increases in critical illness associated with sepsis, burns and trauma, among others, or in association with certain drugs or toxin exposures. Systemically dysregulated fluid homeostasis, which can lead to hypovolaemia, hypotensive shock and widespread tissue oedema, has been termed systemic capillary leak syndrome (SCLS) when overt secondary causes (for example, heart or liver failure) are excluded.
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