[Phenotypes of arterial pressure in young men].

Aim: To study with the use of repetitive clinical measurements and 24-hour arterial pressure (AP) monitoring phenotypes of AP in young men aged 18-25 years with history of elevation of AP at accidental determination.

Material And Methods: We examined 194 young men (mean age 21.1+/-2.1 years) because of detection of elevated AP at casual measurements. Clinical AP was assessed at repetitive determinations in sitting position at the same time on 5 consecutive days. 24-hour AP monitoring (24-HAPM) was carried out according to standard method. Classification of AP level and phenotype was made in accordance with recommendations of European Society of Arterial Hypertension (AH) (2007).

Results: Optimal clinical AP was found in 13 (6.7%), normal AP - in 20 (10.3%), high normal AP - in 24 (12,4%), stable AH - in 107 (55.2%) young men. Eighty one persons (41.8%) had I, 20 (10.3%) - II, and 6 (3.1%) - III degree AH. Among studied patients with stable elevation of clinical AP rate of isolated systolic AH (ISAH) was 65.4%, systole-diastolic AH - 6.1%, isolated diastolic AH - 8.4%. Comparison of levels of clinical AP and 24-HAPM showed that 34 young men (17.5%) had white coat hypertension, 73 (37.6%) - had true AH, 13 (6.7%) - concealed AH. The level of clinical SAP turned out to be the sole predictor of concealed AH. Among examined persons 40 (20.6%) had 1, 57 (29.4%) - 2, 34 (17.5%) - 3 or more additional risk factors. Sixty one subjects (31.4%) had metabolic syndrome. No association was established between number of risk factors, presence of metabolic syndrome, and AP phenotype. Left ventricular hypertrophy was revealed in 24.4% of patients with true AH and in 15.2% - with concealed AH.

Conclusion: Dominating type of AH in young men is ISAH. The data obtained evidence for importance of 24-HAPM for establishment of AP phenotype in young men with normal and high normal clinical AP.