AI Article Synopsis
- A new catalyst system enables the intramolecular acylation of aldehydes using aryl bromides through C-H functionalization.
- The process shows impressive tolerance to different functional groups, which means it can work well with various starting materials.
- This method allows for the creation of highly functionalized benzocyclobutenones featuring a range of substitution patterns, using simple and readily available precursors.
Article Abstract
A new catalyst system for the intramolecular acylation of aldehydes with aryl bromides via C-H functionalization is described. The transformation is distinguished by a remarkable functional group tolerance and hence allows for the synthesis of a wide variety of highly functionalized benzocyclobutenones with a diverse set of substitution patterns from simple and easily accessible precursors.
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| http://dx.doi.org/10.1021/ja909811t | DOI Listing |
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