A comparative study of the platelet resistance to different effects was conducted in patients with chronic schizophrenia and healthy controls using column chromatography on sepharose CL-2B with the incubation at 5 degrees C during 18 h. This method allows to reveal the greater platelet activation in patients compared to the controls. The platelet number in platelet rich plasma (PRP) obtained by centrifugation was 1,8 times less in male patients with chronic schizophrenia than in the controls. This considerable decrease of platelet number in patients may be associated with the platelet deficiency in the blood stream and/or the destruction of activated platelets during blood sampling and centrifugation for the PRP preparation.
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