Over the past decade, molecularly targeted therapies have been added to cytotoxic and antiendocrine drugs in the treatment of cancer, with the aim of targeting the molecular pathways that underlie the carcinogenic process and maintain the cancer phenotype. Success with some of these agents has suggested that identification and validation of drug targets is the starting point for the development of active, safe, and effective drugs. The main molecular targets used to develop anticancer drugs are cell surface receptors, signal transduction pathways, gene transcription targets, ubiquitin-proteasome/heat shock proteins, and tumor microenvironment components. Here, we review the development of the main molecularly targeted noncytotoxic agents studied in glioma, highlighting lessons derived from the development of these novel drugs and proposing new horizons for the clinical development of molecularly targeted therapies.
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| http://dx.doi.org/10.1002/ana.21793 | DOI Listing |
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Preparation of a novel RAM-MIP for selective solid-phase extraction and gas chromatography determination of heptachlor, endosulfan and their metabolite residues in pork.
Anal Methods
November 2017
College of Environmental and Chemical Engineering, Nanchang Hangkong University, Nanchang 330063, China.
A novel method was established using a restricted access material combined with a molecularly imprinted polymer (RAM-MIP) as the sorbent material in solid phase extraction (SPE) for clean-up of α-endosulfan, β-endosulfan, endosulfate, endosulfan-ether, endosulfan lactone, heptachlor, heptachlor--epoxide, and heptachlor--epoxide in pork and gas chromatography (GC) for determination. The RAM-MIP was prepared by precipitation polymerization by using endosulfan as the template, methacrylic acid (MAA) as the monomer, glycidyl methacrylate (GMA) as the pro-hydrophilic co-monomer, ethylene glycol dimethacrylate (EGDMA) as the crosslinker, azobisisobutyronitrile (AIBN) as the initiator, and toluene as the porogen. Ultraviolet spectroscopy (UV) and H-nuclear magnetic resonance (H-NMR) analysis verified that MAA interacted specifically with endosulfan in a ratio of 1 : 1 in the pre-polymerization solution.
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Departamento de Sanidad Animal, Grupo de Investigación en Sanidad Animal y Zoonosis (GISAZ), UIC Zoonosis y Enfermedades Emergentes ENZOEM, Universidad de Córdoba, 14014 Córdoba, Spain; CIBERINFEC, ISCIII CIBER de Enfermedades Infecciosas, Instituto de Salud Carlos III, 28029 Madrid, Spain.
Although wild and domestic carnivores share some haemotropic Mycoplasma species, information about the circulation of this pathogen in grey wolves (Canis lupus) populations is still very limited. Thus, a geographically broad-based investigation was performed for determining the occurrence and diversity of Mycoplasma spp. in three different wolf populations from southern Europe.
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3D genomic features across >50 diverse cell types reveal insights into the genomic architecture of childhood obesity.
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The prevalence of childhood obesity is increasing worldwide, along with the associated common comorbidities of type 2 diabetes and cardiovascular disease in later life. Motivated by evidence for a strong genetic component, our prior genome-wide association study (GWAS) efforts for childhood obesity revealed 19 independent signals for the trait; however, the mechanism of action of these loci remains to be elucidated. To molecularly characterize these childhood obesity loci, we sought to determine the underlying causal variants and the corresponding effector genes within diverse cellular contexts.
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