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The Validation of a Novel, Sex-Specific LDL-Cholesterol Equation and the Friedewald, Sampson-NIH, and Extended-Martin-Hopkins Equations Against Direct Measurement in Korean Adults.
Metabolites
January 2025
Department of Laboratory Medicine, Konkuk University School of Medicine, Seoul 05030, Republic of Korea.
: The currently established equations for calculating low-density lipoprotein cholesterol (LDLc) do not reflect the sex-specific differences in lipid metabolism. We aimed to develop a sex-specific LDLc equation (SSLE) and validate it with three established equations (Friedewald, Sampson-NIH, and ext-Martin-Hopkins) against direct LDLc measurement in Korean adults. This study included 23,757 subjects (51% male; median age, 51 years) from the 2009-2022 Korean National Health and Nutrition Examination Survey.
View Article and Find Full Text PDFCorrelation Analysis of Direct LDL Measurement and Calculated LDL Methods in Lipid Profile Assessment: A Comprehensive Study.
EJIFCC
December 2024
Department of Biochemistry, Srinivasan Medical College and Hospital, Dhanalakshmi Srinivasan University, Tamil Nadu, India.
Introduction: Assessing LDL cholesterol is pivotal for cardiovascular risk evaluation. While direct LDL measurement is accurate, calculated LDL methods offer practicality and cost-effectiveness. This study aims to evaluate the correlation between direct LDL measurement and various calculated LDL methods, shedding light on their clinical utility.
View Article and Find Full Text PDFIntroduction: An annual fasting lipid panel (FLP) is recommended for patients with diabetes, with more frequent testing advised during the escalation of cholesterol-lowering therapy. However, the calculated low-density lipoprotein cholesterol (LDL-C) using the Friedewald equation becomes unreliable when triglycerides are ≥400 mg/dL. In such cases, providers must order a separate direct LDL-C assay to obtain accurate results.
View Article and Find Full Text PDFThe variability of measured and calculated low-density lipoprotein (LDL) cholesterol in statin-treated diabetes patients.
Ann Clin Biochem
December 2024
Allam Diabetes Centre, Hull University Teaching Hospitals NHS Trust, Hull, UK.
Background: The Sampson-NIH and Martin-Hopkins low-density lipoprotein cholesterol (LDL-C) equations are advocated as being superior to the Friedewald calculation. However, their mathematical complexity means they may have different biological and analytical variation when tracking LDL-C in the same patient. This study has established the biological variation (BV) of calculated and directly measured LDL-C (dLDL-C) in patients taking equivalent doses of a long (atorvastatin) and short (simvastatin) half-life statin.
View Article and Find Full Text PDFEvaluation of Lipid Profile Management in Coronary Artery Disease Patients on Statin Therapy: A Single-Centre, Retrospective, Observational Study.
Cureus
October 2024
Internal Medicine, Dr. D. Y. Patil Medical College, Hospital, and Research Centre, Dr. D. Y. Patil Vidyapeeth (Deemed to be University), Pune, IND.
Article Synopsis
- Lipid control is vital for reducing cardiovascular risk in patients with coronary artery disease (CAD), and this study assessed how well statin therapy works in achieving target lipid levels.
- Conducted at a medical college in India, the study reviewed data from 72 adult patients with various types of coronary syndromes, measuring their low-density lipoprotein cholesterol (LDL-C) levels against established guidelines.
- Results indicated that many patients still had high LDL-C levels despite being on statin therapy, pointing to the need for improved treatment strategies for better lipid management in CAD patients.
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