AI Article Synopsis
- Gorham-Stout disease, also known as massive osteolysis, is a rare condition marked by spontaneous and persistent loss of bone in one or more areas, with no effective treatments available.
- The case highlighted involves a patient with a mandibular fracture who was on alendronate, a medication typically used to treat this disease, illustrating the complexity of managing the condition.
- The report aims to share insights on treatment approaches while contributing to the understanding of this challenging and severe disease.
Article Abstract
Gorham-Stout disease, or massive osteolysis, is an extremely rare idiopathic condition characterized by spontaneous, localized relentless resorption of one or several contiguous bones. There is no known successful treatment. Autologous bone graft also resorbs. It is a condition with difficult diagnosis, treatment, and prognosis. We report an extreme case of massive osteolysis of the maxillofacial complex. Unique to this case is that the patient presented with a mandibular fracture, and was taking alendronate (Fosamax), one of the treatment options for patients with Gorham-Stout disease. We discuss our treatment and add to the growing list of patients who have presented with this devastating disease.
Download full-text PDF |
Source |
|---|---|
| http://dx.doi.org/10.1016/j.tripleo.2009.08.045 | DOI Listing |
Publication Analysis
Top Keywords
Similar Publications
Complex lymphatic anomalies.
Pediatr Radiol
January 2025
Department of Radiology, Children's Hospital of Philadelphia, Philadelphia, PA, USA.
Complex lymphatic anomalies are unique diseases marked by abnormal lymphatic vessel development and growth. Imaging is crucial in the evaluation and management of complex lymphatic anomalies, with dynamic contrast-enhanced MR lymphangiography emerging as a valuable modality for visualizing abnormal lymphatic structures and informing treatment decisions. This article gives an overview of complex lymphatic anomalies and their management strategies, focusing specifically on generalized lymphatic anomaly, Gorham-Stout disease, Kaposiform lymphangiomatosis, and central conducting lymphatic anomalies.
View Article and Find Full Text PDFSuccessful Management of Chronic Chylothorax Secondary to Gorham-Stout Disease.
Ann Thorac Surg Short Rep
December 2024
Thoracic Surgery Department, Nottingham University Hospitals NHS Trust, UK.
Gorham-Scout disease (GSD) is a rare skeletal disorder of unknown etiology characterized by progressive osteolysis and excessive lymphovascular proliferation. Chylothorax is a life-threatening complication. A teenager presented with a left pleural effusion on a background of chronic flank collection secondary to lymphovascular malformation.
View Article and Find Full Text PDFSurgical treatment of Gorham-Stout disease combined with scoliosis: a case report and literature review.
BMC Musculoskelet Disord
December 2024
Department of Orthopaedic Surgery, Peking Union Medical College Hospital, Peking Union Medical College, Chinese Academy of Medical Science, Beijing, People's Republic of China.
Background: Gorham-Stout disease (GSD) is a rare disease characterized by osteolysis and lymphatic malformations. GSD involving the spine is exceptionally rare and lacks a standard cure. The aim of this article was to report a case of GSD with scoliosis treated via corrective surgery and medication.
View Article and Find Full Text PDFTibiopelvic Rotational Arthroplasty for Pediatric Gorham-Stout Disease: A Case Report and Surgical Technique.
JBJS Case Connect
October 2024
Department of Orthopaedics, Texas Scottish Rite Hospital for Children, Dallas, Texas.
Case: This is a case of a 6-year-old patient diagnosed with Gorham-Stout disease (GSD), a rare lymphangiogenic skeletal disorder, localized to the left femur. Initial nonoperative treatment with pharmaceuticals and bracing was unsuccessful. We describe a definitive operative treatment with radical femoral resection and a modified rotationplasty technique through a tibiopelvic rotational hip arthroplasty.
View Article and Find Full Text PDFInhibition of EGFR Pathway Suppresses M1 Macrophage Polarization and Osteoclastogenesis, Mitigating Titanium Particle-Induced Bone Resorption.
J Inflamm Res
November 2024
Department of orthopedics, the Affiliated Changzhou Second People's Hospital of Nanjing Medical University, Changzhou, People's Republic of China.
Purpose: The polarization of macrophages towards the pro-inflammatory M1 phenotype and osteoclast overactivation play a significant role in the pathogenesis of aseptic loosening of orthopedic implants. This study sought to examine the expression and activation of macrophages and osteoclasts in implant biopsies with respect to epidermal growth factor receptor (EGFR) signaling and to assess the potential of EGFR inhibition in mitigating titanium particle-induced bone resorption in a cranial resorption murine model.
Methods: Bone marrow-derived macrophages (BMDMs) were stimulated with Tumor Necrosis Factor-alpha (TNF-α) and Interferon-gamma (IFN-γ) initially.
Want AI Summaries of new PubMed Abstracts delivered to your In-box?
Enter search terms and have AI summaries delivered each week - change queries or unsubscribe any time!