[Studies on the chemical constituents of Coleus forskohlii].

Zhong Yao Cai

School of Pharmacy, Fudan University, Shanghai 200032, China.

Published: September 2009

Objective: To study the chemical constituents in the aerial parts of Coleus forskohlii.

Methods: The compounds were isolated by various column chromatographic methods, and their structures were identified by spectroscopic methods.

Results: Twelve compounds were isolated and identified as chamaecydin (1), 6 alpha-hydroxydemethylcryptojaponol (2), alpha-cedrene (3), oleanolic acid (4), forskolin G (5), forskolin J (6), 1,6-diacetyl-9-deoxyforskolin (7), forskolin A (8), forskolin H (9), 6-acetyl-1-deoxyforskolin (10), betulinic acid (11), beta-sitosterol (12).

Conclusion: Compounds 1 - 3 are isolated from Coleus genus for the first time, and compound 4 is isolated from C. forskohlii for the first time.

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