AI Article Synopsis
- Representative benzimidazopyrimidinones are known to be effective antitumor agents by intercalating with DNA.
- The study focused on 2-substituted 4,10-dihydrobenzo [4,5]imidazo[1,2-alpha]pyrimidin-4-ones and explored their potential for functional diversity through regioselective alkylation.
- This process successfully produced 10-alkyl derivatives, enabling the creation of a comprehensive library of 500 new compounds for further investigation.
Article Abstract
Representative benzimidazopyrimidinones were previously reported to be intercalating antitumor agents. In this work, we used 2-substituted 4,10-dihydrobenzo [4,5]imidazo[1,2-alpha]pyrimidin-4-ones for their diversification by regioselective alkylation. Under the conditions established, the alkylation gave 10-alkyl derivatives which permitted the parallel generation of a 500-member library of the title compounds.
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Source |
|---|---|
| http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6254725 | PMC |
| http://dx.doi.org/10.3390/molecules14125223 | DOI Listing |
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