AI Article Synopsis
- A common genetic variant at 9p21 is linked to higher risk of peripheral arterial disease (PAD) and lower Ankle-Brachial Index (ABI) in older individuals.
- In a study involving 2,630 participants aged around 76 years, the C allele at rs1333049 was found to significantly affect ABI and PAD prevalence, even when excluding cases of previous heart attacks.
- The associations held true after accounting for various atherosclerosis risk factors like diabetes, smoking, and high cholesterol levels.
Article Abstract
Background: A common variant at chromosome 9p21 (tagged by the rs1333049 or rs10757278 single-nucleotide polymorphism) is strongly associated with myocardial infarction and major arterial aneurysms. An association with peripheral arterial disease (PAD) was also reported in a sample younger than 75 years, but this disappeared on removal of respondents with a myocardial infarction history, resulting in an odds ratio of 1.09 for PAD (P=0.075). We aimed at estimating the association of this variant with an Ankle-Brachial Index (ABI) and PAD in 3 older populations.
Methods And Results: We used data from the InCHIANTI, Baltimore Longitudinal Study of Aging, and Health, Aging, and Body Composition studies. In 2630 white individuals (mean age, 76.4 years), the C allele at rs1333049 was associated with lower mean ABI measures and with an increased prevalence of PAD. These associations remained after removal of baseline and incident myocardial infarction cases over a 6-year follow-up for both ABI (-0.017 ABI units; 95% CI, -0.03 to -0.01; P = 1.3 x 10(-4)) and PAD (per allele odds ratio, 1.29; 95% CI, 1.06 to 1.56; P = 0.012). These associations also remained after adjustment for known atherosclerosis risk factors, including diabetes mellitus, smoking, hypercholesterolemia, and hypertension.
Conclusions: The C allele at rs1333049 is associated with an increased prevalence of PAD and lower mean ABI. This association was independent of the presence of diagnosed myocardial infarction and atherosclerotic risk factors in 3 older white populations.
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| http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2777723 | PMC |
| http://dx.doi.org/10.1161/CIRCGENETICS.108.825935 | DOI Listing |
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