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Pancreatitis Due to a Giant Simple Hepatic Cyst.
Intern Med
December 2024
Division of Gastroenterology, Department of Internal Medicine, Showa University Fujigaoka Hospital, Japan.
Establishment and characterization of NCC-GCTB10-C1: a novel cell line derived from a patient with recurrent giant cell tumor of bone.
Hum Cell
December 2024
Division of Rare Cancer Research, National Cancer Center Research Institute, 5-1-1 Tsukiji, Chuo-Ku, Tokyo, 104-0045, Japan.
Giant cell tumor of bone (GCTB) is a rare osteolytic tumor composed of mononuclear stromal cells, macrophages, and osteoclast-like giant cells. While generally benign, GCTB has a high risk of local recurrence and can occasionally undergo malignant transformation or metastasis, posing significant clinical challenges. The primary treatment is complete surgical resection; however, effective management strategies for recurrent or advanced GCTB remain elusive, underscoring the need for further preclinical research.
View Article and Find Full Text PDFPrimary dedifferentiated liposarcoma of the gallbladder: a case report and literature review.
Front Surg
November 2024
Department of Hepatobiliary and Pancreatic Surgery, The First Hospital of Jilin University, Changchun, China.
Background: Liposarcoma (LPS) is a kind of malignancy of soft tissue usually found in the retroperitoneal, limb, or neck region, and some may be detected with delayed symptoms (pain or palpable mass), and less frequently occurs in organs of the digestive system. In contrast, Dedifferentiated liposarcoma (DDLPS) is a common histological subtype of LPS. The present study reported a case of dedifferentiated liposarcoma originating in the gallbladder.
View Article and Find Full Text PDFCross-domain binding of anti-fibrillation peptide TNGQ to islet amyloid polypeptide provides cytoprotective effects in giant unilamellar vesicles and pancreatic β-cells.
Food Funct
December 2024
School of Nutrition Sciences, Faculty of Health Sciences, University of Ottawa, Ottawa, K1H 8M5, Canada.
Islet amyloid polypeptide (IAPP) fibrillation induces β-cell dysfunction and toxicity in patients with type 2 diabetes. Cytotoxicity is caused by the ability of IAPP fibrils and fibrillar intermediates to permeate the cellular membrane of pancreatic β-cells, trigger endoplasmic reticular stress, induce reactive oxygen species production, and upregulate apoptosis-related genes. Thus, inhibition of IAPP fibrillation is of great interest for preventing associated cytotoxicity.
View Article and Find Full Text PDFAltered galectin-3 distribution and migratory function in the pre-diabetic non-obese diabetic mouse thymus.
Front Endocrinol (Lausanne)
November 2024
Laboratory on Thymus Research, Oswaldo Cruz Institute, Oswaldo Cruz Foundation, Rio de Janeiro, RJ, Brazil.
Galectin-3 is an endogenous lectin which binds mainly to β-galactosides on the cell surface and extracellular matrix (ECM) glycoproteins. In the thymus, this lectin is constitutively expressed, being involved in thymocyte adhesion, migration, and death. Galectin-3 has been related to type 1 diabetes, an autoimmune disease characterized by pancreatic β-cell destruction mediated by autoreactive T lymphocytes.
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