Allergic rhinitis is one of the most common chronic diseases with over 600 million people affected worldwide. More than 200 million of them also suffer from concomitant asthma. Allergic rhinitis is generally under-diagnosed and under-treated. A significant burden of allergic rhinitis is due to pet allergies. In 2008 two major evidence-based documents on the management of allergic rhinitis were published, namely the US Rhinitis Practice Parameters and the ARIA/WHO Guidelines that stress the burden of allergic rhinitis due to animal allergens and the comorbidities of allergic rhinitis. We need a new approach targeting individual disease control in rhinitis due to animal allergens emphasizing avoidance and active treatment. The goals of the avoidance-treatment are to first improve patient care by recognizing each individual patient's burden of disease and expectations of therapy, and then to target and adjust the appropriate therapies to meet these expectations. Achieving these goals will, ultimately, help the patient to better self-manage his or her disease, thereby improving overall quality of life.
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http://dx.doi.org/10.2500/aap.2009.30.3297 | DOI Listing |
Introduction: To investigate how adipose-derived mesenchymal stem cells (ADSCs) regulate the balance between regulatory T cells (Treg) and Th17 cells through the IL-2/JAK3/STAT5 signaling pathway in a rat model of allergic rhinitis (AR).
Methods: Adipose-derived stem cells (ADSCs) were used to treat an ovalbumin (OVA)-induced AR rat model. The pathological changes and nasal symptoms were observed by HE staining and scanning electron microscopy.
J Clin Med
January 2025
Department of Pediatrics "Mother and Child", Faculty of Medicine, University of Medicine and Pharmacy of Craiova, 200349 Craiova, Romania.
Asthmatic children who tested positive for COVID-19 experienced changes in lung function and persistent symptoms following SARS-CoV-2 infection, even for several months after diagnosis, and with the same features as in an acute phase. This study aimed to analyze a pediatric age group (between 0 and 17 years old) diagnosed with asthma, and SARS-CoV-2 infection attending regular monitoring visits in a Pediatric Department of a Regional Tertiary Hospital (Filantropia Clinical Municipal Hospital Craiova, Romania) during the COVID-19 pandemic and post-pandemic time interval (i.e.
View Article and Find Full Text PDFInt J Mol Sci
January 2025
Department of Experimental Medicine, Sapienza University of Rome, 00161 Rome, Italy.
Alcohol is the second-most misused substance after tobacco. It has been identified as a causal factor in more than 200 diseases and 5.3% of all deaths and is associated with significant behavioral, social, and economic difficulties.
View Article and Find Full Text PDFMedicina (Kaunas)
January 2025
Division of Allergy Immunology, Department of Child Health, Doctoral Study Program, Faculty of Medicine, Universitas Padjadjaran, Bandung 45363, West Java, Indonesia.
: The prevalence of stunted children under 5 years in Indonesia is relatively high. Stunting is a significant risk factor for wheezing disorders. The asthma predictive index (API) identifies children with a recurrent wheezing disorder at risk of developing asthma during the first 3 years.
View Article and Find Full Text PDFMedicina (Kaunas)
January 2025
Division of Allergy/Immunology, Department of Pediatrics, Jackson Memorial Holtz Children's Hospital, University of Miami Miller School of Medicine, Miami, FL 33136, USA.
Inborn errors of immunity (IEIs), also known as primary immunodeficiencies, are a group of genetic disorders affecting the development and function of the immune system. While IEIs traditionally present with recurrent infections, an increasing number of cases manifest with early-onset severe atopy, including atopic dermatitis, food allergies, asthma, and allergic rhinitis-features that are often overlooked. This can lead to delayed diagnosis and treatment, which is crucial for IEI patients due to the risk of severe infections.
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