Novel 1-[[4-(4-bromophenyl)-5-(2-furyl)-4H-1,2,4-triazole-3-yl]mercaptoacetyl]-4-alkyl/aryl-3-thiosemicarbazides (5-12) were synthesized by the reaction of 4-(4-bromophenyl)-5-(2-furyl)-4H-1,2,4-triazole-3-ylmercaptoacetylhydrazide (4) with substituted isothiocyanates. Cyclodehydration of thiosemicarbazides with concentrated sulfuric acid yielded 2-[4-(4-bromophenyl)-5-(2-furyl)-4H-1,2,4-triazole-3-yl]mercaptomethyl-5-alkyl/arylamino-1,3, 4-thiadiazoles (13-17). The new compounds were evaluated for in vitro antifungal activity using the microdilution method. The tested compounds showed varying degrees of activity against Microsporum gypseum NCPF-580, Microsporum canis, Trichophyton mentagrophytes, Trichophyton rubrum, and Candida albicans ATCC 10231 (MIC 8-4 microg/mL).

Download full-text PDF

Source
http://dx.doi.org/10.3109/14756360903040439DOI Listing

Publication Analysis

Top Keywords

synthesis structure
4
structure antifungal
4
antifungal evaluation
4
evaluation novel
4
novel 124-triazolylmercaptoacetylthiosemicarbazide
4
124-triazolylmercaptoacetylthiosemicarbazide 124-triazolylmercaptomethyl-134-thiadiazole
4
124-triazolylmercaptomethyl-134-thiadiazole analogs
4
analogs novel
4
novel 5-12
4
5-12 synthesized
4

Similar Publications

Want AI Summaries of new PubMed Abstracts delivered to your In-box?

Enter search terms and have AI summaries delivered each week - change queries or unsubscribe any time!