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Neohesperidin Improves Depressive-Like Behavior Induced by Chronic Unpredictable Mild Stress in Mice.
Neurochem Res
January 2025
Precision Pharmacy & Drug Development Center, Department of Pharmacy, Tangdu Hospital, Air Force Medical University, Xi'an, 710038, China.
Depression is a common and complex neuropsychiatric disorder affecting people of all ages worldwide, associated with high rates of relapse and disability. Neohesperidin (NEO) is a dietary flavonoid with applications in therapeutics; however, its effects on depressive-like behavior remain unknown. Here, we evaluated the effects of NEO on depressive-like behavior induced by chronic and unpredictable mild stress (CUMS).
View Article and Find Full Text PDFMulti-Omics Research on Angina Pectoris: A Novel Perspective.
Aging Dis
December 2024
Department of Psycho-cardiology, Beijing Anzhen Hospital, Capital Medical University, Beijing, China.
Angina pectoris (AP), a clinical syndrome characterized by paroxysmal chest pain, is caused by insufficient blood supply to the coronary arteries and sudden temporary myocardial ischemia and hypoxia. Long-term AP typically induces other cardiovascular events, including myocardial infarction and heart failure, posing a serious threat to patient safety. However, AP's complex pathological mechanisms and developmental processes introduce significant challenges in the rapid diagnosis and accurate treatment of its different subtypes, including stable angina pectoris (SAP), unstable angina pectoris (UAP), and variant angina pectoris (VAP).
View Article and Find Full Text PDFUnlocking ABA's role in rice cold tolerance: insights from Zhonghua 11 and Kasalath.
Theor Appl Genet
January 2025
College of Agriculture, Hunan Agricultural University, Changsha, 410128, Hunan, China.
Unraveling key ABA pathways, including OsWRKY71-OsABA8ox1 and OsbZIP73-OsNCED5, provides valuable insights for improving cold tolerance in rice breeding for cold-prone regions. Cold stress limits rice (Oryza sativa L.) production in cooler climates.
View Article and Find Full Text PDFClinical Manifestations.
Alzheimers Dement
December 2024
University of California Los Angeles, Los Angeles, CA, USA.
Background: Unsupervised high-frequency cognitive-ecological momentary assessment (EMA) on smartphones is increasingly used to assess preclinical risk for Alzheimer's disease and related dementias (ADRD). While these tests are reliable and valid for individuals with preclinical ADRD, it is unclear whether administering cognitive EMAs to people living with ADRD is feasible and valid. Our study explored the feasibility and validity on cognitive EMA tests in people living with moderate to severe ADRD.
View Article and Find Full Text PDFBackground: Predicting decline over the course of Mild Cognitive Impairment (MCI) and Alzheimer's Disease (AD), especially on relatively short time frames, is vital for appropriate treatment planning and to tailor patient and support systems' expectations. The current study tested if a functional upper limb motor learning task could predict one-year change in cognition and daily function.
Method: Cognitively unimpaired (n = 61), MCI (n = 35), and AD (32) older subjects (age: 74.
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