AI Article Synopsis
Article Abstract
Background: Alterations in arterial absolute distension (AD) and relative distension (RD) in the common carotid artery (CCA), as observed by ultrasound, may relate to atherosclerotic processes in a nearby vascular segment. The main objective of the study was to establish to what extent these mechanical vascular alterations relate to carotid bulb stenosis.
Methods: The AD, RD and their interrecording variation (Delta AD and Delta RD), representing the spatial inhomogeneity of AD and RD, were evaluated in 308 CCA and associated with the degree of bulb stenosis.
Results: The mechanical CCA parameters were marginally correlated to the degree of ipsilateral (r = -0.14 for AD and r = -0.28 for RD) and contralateral stenosis (r = -0.21 for AD and r = -0.27 for RD). However, Delta AD (r = 0.54; p < 0.001) and Delta RD (r = 0.59; p < 0.001) were significantly correlated to ipsilateral stenosis, independent of age, gender and pulse pressure.
Conclusions: The indices of CCA arterial stiffness are weakly associated with ipsilateral bulb stenosis, but their interrecording variation is a good indicator for atherosclerotic alterations in the carotid bulb. The results indicate that a focal atherosclerotic lesion is associated with modifications in the dynamic characteristics of a nearby vascular segment.
Download full-text PDF |
Source |
|---|---|
| http://dx.doi.org/10.1159/000267280 | DOI Listing |
Publication Analysis
Top Keywords
Similar Publications
Advancing Vascular Surgery: The Role Of Artificial Intelligence And Machine Learning In Managing Carotid Stenosis.
Port J Card Thorac Vasc Surg
October 2024
RISE@Health, Rua Dr. Plácido da Costa, Porto, Portugal; Department of Biomedicine - Unit of Anatomy, Faculdade de Medicina da Universidade do Porto, Portugal.
Introduction: Cardiovascular diseases affect 17.7 million people annually, worldwide. Carotid degenerative disease, commonly described as atherosclerotic plaque accumulation, significantly contributes to this, posing a risk for cerebrovascular events and ischemic strokes.
View Article and Find Full Text PDFCost-Effectiveness Analysis of Inclisiran for the Treatment of Primary Hypercholesterolemia or Mixed Dyslipidemia in Singapore.
Value Health Reg Issues
January 2025
Novartis Singapore Pte Ltd, Singapore. Electronic address:
Objectives: This analysis evaluated the cost-effectiveness of inclisiran plus standard of care (SoC; comprising statins, ezetimibe, and fenofibrate) in primary hypercholesterolemia or mixed dyslipidemia from a Singapore healthcare system perspective. Inclisiran + SoC was separately compared with SoC, alirocumab + SoC, and evolocumab + SoC.
Methods: A lifetime Markov model in the United Kingdom (UK) was adapted to the Singapore setting.
Patch-Wise Deep Learning Method for Intracranial Stenosis and Aneurysm Detection-the Tromsø Study.
Neuroinformatics
January 2025
Department of Clinical Medicine, UiT the Arctic University of Norway, Tromsø, Norway.
Intracranial atherosclerotic stenosis (ICAS) and intracranial aneurysms are prevalent conditions in the cerebrovascular system. ICAS causes a narrowing of the arterial lumen, thereby restricting blood flow, while aneurysms involve the ballooning of blood vessels. Both conditions can lead to severe outcomes, such as stroke or vessel rupture, which can be fatal.
View Article and Find Full Text PDFTianxiangdan suppresses foam cell formation by enhancing lipophagy and reduces the progression of atherosclerosis.
In Vitro Cell Dev Biol Anim
January 2025
College of Traditional Chinese Medicine, Xinjiang Uygur Autonomous Region, Xinjiang Medical University, Urumqi, 830063, China.
The aim of this study is to assess the impact of Tianxiangdan (TXD) on lipophagy in foam cells and its underlying mechanism in treating atherosclerosis, particularly focusing on its efficacy in lowering blood lipids. In vivo, ApoE-/- atherosclerosis mouse models were established for group intervention. Blood lipid levels of the mice were measured, lipid deposition and autophagy levels in atherosclerotic plaques were assessed, and co-localization of lipid droplets and autophagosomes was examined.
View Article and Find Full Text PDFUrolithin B suppresses phenotypic switch in vascular smooth muscle cells induced by PDGF-BB via inhibiting the PI3K-AKT pathway.
In Vitro Cell Dev Biol Anim
January 2025
School of Basic Medical Sciences, Southwest Medical University, No. 1 Section 1, Xianglin Road, Longmatan District, Luzhou, 646000, Sichuan, China.
Atherosclerosis (AS) is a prevalent cardiovascular condition, and the growth and phenotypic switch of vascular smooth muscle cells (VSMCs) play a crucial role in its development. Studies have revealed that the activation of certain transcription factors and signaling pathways can trigger these cellular changes. Consequently, targeting these pathways and pivotal molecules has emerged as a promising strategy for AS treatment.
View Article and Find Full Text PDFWant AI Summaries of new PubMed Abstracts delivered to your In-box?
Enter search terms and have AI summaries delivered each week - change queries or unsubscribe any time!