Intermediate uveitis (IU) is described as inflammation in the anterior vitreous, ciliary body and the peripheral retina. In the Standardization of Uveitis Nomenclature (SUN) working group's international workshop for reporting clinical data the consensus reached was that the term IU should be used for that subset of uveitis where the vitreous is the major site of the inflammation and if there is an associated infection (for example, Lyme disease) or systemic disease (for example, sarcoidosis). The diagnostic term pars planitis should be used only for that subset of IU where there is snow bank or snowball formation occurring in the absence of an associated infection or systemic disease (that is, "idiopathic"). This article discusses the clinical features, etiology, pathogenesis, investigations and treatment of IU.
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http://dx.doi.org/10.4103/0301-4738.58469 | DOI Listing |
Am J Ophthalmol Case Rep
June 2025
Department of Ophthalmology, Hamad Medical Corporation, Doha, Qatar.
Purpose: To report a case of rhegmatogenous retinal detachment (RRD) caused by spontaneous retinal dialysis in intermediate uveitis due to multiple sclerosis (MS).
Observations: A 29-year-old Middle Eastern female, was diagnosed with MS following an episode of bilateral intermediate uveitis. Later, she presented with sequential RRD in both eyes.
BMJ Open Ophthalmol
February 2025
Department of Ophthalmology, National Defense Medical College, Tokorozawa, Saitama, Japan
Introduction: Rho-associated protein kinases (ROCKs) are a key regulator of T cell function, influencing a wide range of processes from activation to differentiation. Experimental autoimmune uveoretinitis (EAU) is an animal model of human non-infectious uveitis. This study aimed to evaluate the suppressive effects of ripasudil, a ROCK inhibitor, on ocular inflammation when administered from the onset of EAU and to elucidate the underlying mechanisms of its inhibitory effects.
View Article and Find Full Text PDFCase Rep Ophthalmol Med
February 2025
Department of Ophthalmology & Visual Sciences, SUNY Upstate Medical University, Syracuse, New York, USA.
Sarcoidosis is a systemic inflammatory disease associated with ocular involvement in 20%-30% of cases. The current gold standard for detecting sarcoidosis is computed tomography of the thorax, which is 73% sensitive. Definitive diagnosis necessitates biopsy, with Schaumann bodies and non-necrotizing granulomas serving as key pathological hallmarks.
View Article and Find Full Text PDFCureus
January 2025
Department of Ophthalmology, Hospital Tuanku Ja'afar, Seremban, MYS.
Anterior uveitis frequently occurs in ocular cytomegalovirus (CMV) infection among immunocompetent individuals. Here, we report a rare instance of bilateral isolated intermediate uveitis without retinitis or retinal vasculitis in an immunocompetent individual, later confirmed to be an ocular CMV infection. He was treated with systemic ganciclovir and topical corticosteroid.
View Article and Find Full Text PDFOcul Immunol Inflamm
February 2025
Department of Ophthalmology, Erciyes University Medical Faculty, Kayseri, Turkey.
Purpose: To present the clinical manifestations, ocular complications and treatment results of pediatric pars planitis (PPP).
Methods: This retrospective clinical study was conducted at a tertiary care center and included 28 children (51 eyes) aged 16 years or younger. Visual acuity (VA), anterior chamber cell (ACC) grade, vitritis grade, central macular thickness (CMT), fundus fluorescein angiography (FFA) score, treatment approach, complications, and relapse rate were recorded.
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