AI Article Synopsis
- A new classification system for gliomas is emerging, combining both histological and molecular features, focusing on key factors like 1p/19q codeletion in anaplastic gliomas and MGMT methylation status in glioblastomas.
- Advanced imaging techniques are enhancing the identification of glioma characteristics and their potential for evolution, highlighting the importance of complete tumor resection and chemotherapy in low-grade gliomas.
- While traditional targeted therapies have struggled to show effectiveness, particularly anti-EGFR treatments, anti-angiogenic therapies are showing promise, with combined chemoradiotherapy being the standard treatment for glioblastomas.
Article Abstract
A better understanding of gliomas biology is now leading to a combined histo-molecular classification of these tumors. In anaplastic gliomas ongoing studies depend on 1p/19q codeletion status and in glioblastomas on MGMT methylation status. Advanced brain tumor imaging elicits a better identification of gliomas evolutive potential of. In low-grade gliomas, the importance of maximal resection and the role of chemotherapy are being increasingly recognized. In anaplastic gliomas, phase III studies have clarified the respective roles of chemotherapy and radiotherapy. In glioblastomas concomitant chemoradiotherapy is the standard. Most targeted therapies, namely anti-EGFR therapies have failed to demonstrate efficacy but anti-angiogenics are promising. The aim of this review is to discuss the main advances in adults' gliomas biology, imaging and treatment.
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| http://dx.doi.org/10.1684/bdc.2009.1019 | DOI Listing |
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