AI Article Synopsis
- The study aimed to explore the metabolomic differences between patients with irritable bowel syndrome (IBS) and healthy controls by analyzing mucosal biopsies from the colon.
- Fifteen IBS patients and nine healthy participants underwent lipidomics and metabolomics analysis, revealing significantly elevated lipid levels and pro-inflammatory markers in IBS patients, including specific fatty acids and ceramides.
- The findings indicate that the mucosal environment in IBS is characterized by a unique pro-inflammatory and lipotoxic metabolic profile, suggesting potential targets for treatment.
Article Abstract
Aim: To investigate the pathophysiology of irritable bowel syndrome (IBS) by comparing the global mucosal metabolic profiles of IBS patients with those of healthy controls.
Methods: Fifteen IBS patients fulfilling the Rome II criteria, and nine healthy volunteers were included in the study. A combined lipidomics (UPLC/MS) and metabolomics (GC x GC-TOF) approach was used to achieve global metabolic profiles of mucosal biopsies from the ascending colon.
Results: Overall, lipid levels were elevated in patients with IBS. The most significant upregulation was seen for pro-inflammatory lysophosphatidylcholines. Other lipid groups that were significantly upregulated in IBS patients were lipotoxic ceramides, glycosphingolipids, and di- and triacylglycerols. Among the metabolites, the cyclic ester 2(3H)-furanone was almost 14-fold upregulated in IBS patients compared to healthy subjects (P = 0.03).
Conclusion: IBS mucosa is characterised by a distinct pro-inflammatory and lipotoxic metabolic profile. Especially, there was an increase in several lipid species such as lysophospholipids and ceramides.
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| http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2797663 | PMC |
| http://dx.doi.org/10.3748/wjg.15.6068 | DOI Listing |
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