Comparative placebo-controlled clinical trials on the efficiency and safety of ultralow doses of antibodies to human IFN-gamma (anaferon pediatric formulation and anaferon) and prophylaxis of bacterial complication showed that administration of these preparations in complex therapy of bacterial infection reduced the incidence of bacterial complications of viral infections and considerably decreased the duration of the main clinical symptoms of the disease.
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http://dx.doi.org/10.1007/s10517-009-0699-4 | DOI Listing |
Background And Aims: Optimization of fluoroscopic image quality for reducing radiation exposure in cryoballoon pulmonary vein isolation (CB-PVI) has not yet been fully investigated. Therefore, we tried to compare the radiation doses among three different X-ray system settings.
Methods: Consecutive 148 patients scheduled for their first CB-PVI were prospectively enrolled: low dose with the use of an anti-scatter grid for the first 51 patients (LD + G group), low dose without an anti-scatter grid for the subsequent 46 patients (LD-G group), and ultralow dose (ULD group) with an anti-scatter grid for the remaining 51 patients.
Mol Ther Nucleic Acids
December 2024
Department of Biochemistry and Molecular Biology III and Immunology, Faculty of Medicine, University of Granada, Av. de la Investigación, 11, 18006 Granada, Spain.
Although chimeric antigen receptor (CAR) T cell therapy has revolutionized type B cancer treatment, efficacy remains limited in various lymphomas and solid tumors. Reinforcing conventional CAR-T cells to release cytokines can improve their efficacy but also increase safety concerns. Several strategies have been developed to regulate their secretion using minimal promoters that are controlled by chimeric proteins harboring transactivators.
View Article and Find Full Text PDFAdv Healthc Mater
November 2024
Department of Experimental Research, Guangxi Medical University Cancer Hospital, Nanning, Guangxi, 530021, China.
The combination of photothermal and chemodynamic therapy (PTT-CDT) using single-atom nanozymes (SAzymes) shows great promise in combating pathogenic and drug-resistant bacteria. However, the photothermal conversion efficiency and catalytic activity of SAzymes with solely metal sites remain inadequate, often requiring high doses for effectiveness. Herein, a bimetallic single-atomic nanozymes with Fe and Cu active sites (FeCu BSNs) designed is reported for efficient treatment of bacterial infections through hyperthermia-amplified nanozyme catalysis strategy.
View Article and Find Full Text PDFBr J Radiol
January 2025
Department of Nuclear Medicine, Zhongshan Hospital, Fudan University, Shanghai, 200032, China.
Acta Radiol
October 2024
Diagnostic and Interventional Radiology, University Hospital Zurich, University of Zurich, Zurich, Switzerland.
Background: Radiation dose should be as low as reasonably achievable. With the invention of photon-counting detector computed tomography (PCD-CT), the radiation dose may be considerably reduced.
Purpose: To evaluate the potential of PCD-CT for dose reduction in pulmonary nodule visualization for human readers as well as for computer-aided detection (CAD) studies.
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