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Weakly Supervised Bayesian Shape Modeling from Unsegmented Medical Images.
Shape Med Imaging (2024)
October 2024
Scientific Computing and Imaging Institute, University of Utah, UT, USA.
Article Synopsis
- Anatomical shape analysis is important in clinical research for understanding how form affects function, and traditional shape modeling methods are often complex and biased due to their reliance on manual processes and assumptions.* -
- Recent advances in deep learning have improved shape modeling from medical images but typically require a fully supervised training process, which still involves the limitations of traditional methods.* -
- The new approach introduces weakly supervised deep learning for shape modeling, using point cloud supervision to simplify the process and achieve accurate predictions without strong supervision while effectively capturing shape variability.*
Recent secondary contact, genome-wide admixture, and asymmetric introgression of neo-sex chromosomes between two Pacific island bird species.
PLoS Genet
August 2024
Department of Biology, University of Rochester, Rochester, New York, United States of America.
Secondary contact between closely related taxa represents a "moment of truth" for speciation-an opportunity to test the efficacy of reproductive isolation that evolved in allopatry and to identify the genetic, behavioral, and/or ecological barriers that separate species in sympatry. Sex chromosomes are known to rapidly accumulate differences between species, an effect that may be exacerbated for neo-sex chromosomes that are transitioning from autosomal to sex-specific inheritance. Here we report that, in the Solomon Islands, two closely related bird species in the honeyeater family-Myzomela cardinalis and Myzomela tristrami-carry neo-sex chromosomes and have come into recent secondary contact after ~1.
View Article and Find Full Text PDFHow hereditary cancer risk disclosure to relatives is handled in practice - Patient perspectives from a Swedish cancer genetics clinic.
Patient Educ Couns
September 2024
Department of Nursing, Umeå University, Umeå, Sweden; Department of Public Health and Clinical Medicine, Family Medicine, Umeå University, Umeå, Sweden.
Objectives: Hereditary cancer risks can be effectively managed if at-risk relatives enroll in surveillance and preventive care. Family-mediated risk disclosure has internationally been shown to be incomplete, selective and leave over a third of eligible at-risk individuals without access to genetic counseling. We explored patients handling of cancer risk information in practice.
View Article and Find Full Text PDFOvercoming Limitations to Deep Learning in Domesticated Animals with TrioTrain.
bioRxiv
April 2024
University of Missouri, Division of Animal Sciences, Columbia, MO, 65201 USA.
Variant calling across diverse species remains challenging as most bioinformatics tools default to assumptions based on human genomes. DeepVariant (DV) excels without joint genotyping while offering fewer implementation barriers. However, the growing appeal of a "universal" algorithm has magnified the unknown impacts when used with non-human genomes.
View Article and Find Full Text PDFDealing With Diversity in Psychology: Science and Ideology.
Perspect Psychol Sci
May 2024
Department of Psychology, Center for the Comparative Study of Race and Ethnicity, Stanford University.
Article Synopsis
- - The author writes about their experiences and challenges in academic discussions, aiming to share important truths that many scholars have faced.
- - They believe that race and racism greatly influence how scholars think and work, and it's important for everyone to recognize these issues.
- - The author thinks that for academic fields to improve and be fair, they need to embrace diversity and be aware of their own biases.
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