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Special Issue "Effects of Dyslipidemia and Metabolic Syndrome on Cardiac and Vascular Dysfunction".
Int J Mol Sci
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Department of Clinical Internal, Anesthesiological and Cardiovascular Sciences, Sapienza University of Rome, Viale del Policlinico 155, 00161 Rome, Italy.
The global increase in dysmetabolic conditions such as hyperglycemia, insulin resistance, dyslipidemia, metabolic syndrome, and type 2 diabetes is becoming a significant healthcare concern [...
View Article and Find Full Text PDFComparison of Muscle Growth and Dynamic Strength Adaptations Induced by Unilateral and Bilateral Resistance Training: A Systematic Review and Meta-analysis.
Sports Med
January 2025
Metabolism, Nutrition and Exercise Laboratory, Physical Education and Sport Center, State University of Londrina, Londrina, Paraná, Brazil.
Background: Currently, great debate exists over the proposed superiority of some resistance exercises to induce muscular adaptations. For example, some argue that unilateral exercise (meaning one limb at a time) is superior to bilateral exercises (meaning both limbs). Of note, an evidence-based answer to this question is yet to be determined, particularly regarding muscle hypertrophy.
View Article and Find Full Text PDFOrganoid models of drug resistant gastric adenosquamous carcinoma: Recapitulating tumor features and refining precision treatment.
Drug Resist Updat
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Digestive Diseases Center, Guangdong Provincial Key Laboratory of Digestive Cancer Research, The Seventh Affiliated Hospital of Sun Yat-sen University, Shenzhen, Guangdong 518107, China; The Biobank, Scientific Research Center, Guangdong Provincial Key Laboratory of Digestive Cancer Research, The Seventh Affiliated Hospital of Sun Yat-Sen University, Shenzhen, Guangdong 518107, China. Electronic address:
Article Synopsis
- Organoids were created from a patient's primary tumor and metastatic lymph nodes, accurately mirroring the tumor's characteristics.
- Drug testing on these organoids showed distinct differences in how they responded to treatments based on their origin (primary vs. metastatic).
- This personalized approach to using organoids aids in making informed treatment decisions for gastric cancer, potentially improving patient outcomes.
Clinical Pharmacokinetics of Antitubercular Drugs in the Overweight and Obese Population: Implications for Dosage Adjustments.
Clin Pharmacokinet
January 2025
Department of Clinical Pharmacology, Medical University of Vienna, Währinger Gürtel 18-20, 1090, Vienna, Austria.
The rise in global obesity prevalence has increased the need to understand the pharmacokinetics of drugs in overweight and obese individuals. Tuberculosis remains a significant health challenge, and its treatment outcomes can be influenced by the pharmacokinetic profiles of antitubercular agents. This literature review aims to point out the clinical pharmacokinetics of antitubercular drugs in the overweight and obese patient population, highlighting considerations for potential dosage adjustments.
View Article and Find Full Text PDFLet-7b-5p sensitizes breast cancer cells to doxorubicin through Aurora Kinase B.
PLoS One
January 2025
Information School, The Wave, The University of Sheffield, Sheffield, United Kingdom.
MicroRNAs (miRNAs) are small, non-coding RNAs that regulate the expression level of the target genes in the cell. Breast cancer is responsible for the majority of cancer-related deaths among women globally. It has been proven that deregulated miRNAs may play an essential role in the progression of breast cancer.
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