AI Article Synopsis
- PCSK9 is an enzyme secreted by the liver that reduces the amount of LDL receptors, leading to increased LDL cholesterol levels.
- PCSK9 and LDL receptors are also found in pancreatic beta cells, which are crucial for insulin production.
- In experiments with PCSK9-null mice, findings indicated these mice had lower insulin levels, higher blood sugar, and issues with their pancreatic islets, suggesting PCSK9 is important for proper pancreatic function.
Article Abstract
Proprotein convertase subtilisin/kexin type 9 (PCSK9), a liver-secreted plasma enzyme, restricts hepatic uptake of low-density lipoprotein (LDL) cholesterol by promoting the degradation of LDL receptors (LDLR). PCSK9 and LDLR are also expressed in insulin-producing pancreatic islet beta cells, possibly affecting the function of these cells. Here we show that, compared to control mice, PCSK9-null male mice over 4 months of age carried more LDLR and less insulin in their pancreas; they were hypoinsulinemic, hyperglycemic and glucose-intolerant; their islets exhibited signs of malformation, apoptosis and inflammation. Collectively, these observations suggest that PCSK9 may be necessary for the normal function of pancreatic islets.
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| http://dx.doi.org/10.1016/j.febslet.2009.12.018 | DOI Listing |
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