This preface introduces articles that appear in the special section on intraindividual variability and aging and illustrate what intraindividual variability might contribute to the study of development. These articles exemplify the variety of conceptual perspectives, analytical methods, and types of data that are being used to study intraindividual variability and illustrate what the study of intraindividual variability might contribute to the study of development.
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Intra-individual variability in ancient plasmodium DNA recovery highlights need for enhanced sampling.
Sci Rep
January 2025
Department of Evolutionary Anthropology, University of Vienna, Vienna, Austria.
Malaria has been a leading cause of death in human populations for centuries and remains a major public health challenge in African countries, especially affecting children. Among the five Plasmodium species infecting humans, Plasmodium falciparum is the most lethal. Ancient DNA research has provided key insights into the origins, evolution, and virulence of pathogens that affect humans.
View Article and Find Full Text PDFImprecision nutrition? Intraindividual variability of glucose responses to duplicate presented meals in adults without diabetes.
Am J Clin Nutr
January 2025
Laboratory of Biological Modeling, National Institute of Diabetes and Digestive and Kidney Diseases, NIH, Bethesda, MD, United States. Electronic address:
Background: Continuous glucose monitors (CGMs) are used to characterize postprandial glucose responses and provide personalized dietary advice to minimize glucose excursions. The efficacy of such advice depends on reliable glucose responses.
Objectives: To explore within-subject variability of CGM responses to duplicate presented meals in an inpatient setting.
Clinical Manifestations.
Alzheimers Dement
December 2024
Hospital del Mar Research Institute (IMIM), Barcelona, Spain.
Background: Objective Subtle Cognitive Decline (obj-SCD) can be identified through standardized neuropsychological tests and may precede the development of Mild Cognitive Impairment (MCI). Nevertheless, current clinical and research criteria lack a standardized protocol for identifying obj-SCD. This study introduces cutting-edge sensitive methods to characterize obj-SCD, defined through Alzheimer's disease (AD) biomarker-based longitudinal cognitive performance in episodic memory.
View Article and Find Full Text PDFClinical Manifestations.
Alzheimers Dement
December 2024
University of Pittsburgh, Pittsburgh, PA, USA.
Background: Characterizing dementia risk is difficult with traditional neuropsychological testing. Ecological Momentary Cognitive Testing (EMCT) uses ecological momentary assessment (EMA) methods to sample daily life cognition. The current study examined how daily activities were related to EMCT performance and explored whether associations remained when stratifying by amyloid-beta (Aβ) status.
View Article and Find Full Text PDFClinical Manifestations.
Alzheimers Dement
December 2024
University of California, San Diego, La Jolla, CA, USA.
Background: Women are more likely to experience sleep problems than men, especially during and after menopausal transition. Sleep disturbances are related to memory decline and the development of Alzheimer's disease (AD), which is also more common among women. While research on habitual sleep patterns in aging has largely focused on mean sleep outcomes across nights, few studies have examined the potentially harmful effects of night-to-night variability in sleep quality on AD biomarkers and memory function.
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