Acute forms of meningo-encephalitis due to West Nile virus are rare. The purpose of this report is to describe the first case of acute meningoencephalitis due to West Nile virus diagnosed in Gabon. The patient was a 20-year-old Gabonese man. Diagnostic was confirmed by molecular biology. The patient died 12 days after admission to the hospital. This case is discussed based on a review of the literature.
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