Cardioinhibitory properties of potato glycoalkaloids in beetles.

Bull Environ Contam Toxicol

Department of Animal Physiology and Development, Adam Mickiewicz University, Umultowska 89 Street, 61-614 Poznan, Poland.

Published: February 2010

The semi-isolated heart bioassay was used to evaluate the effect of glycoalkaloids extracted from potato leaves on the heart contractile activity of three beetle species Zophobas atratus, Tenebrio molitor and Leptinotarsa decemlineata. The dose-response curves indicated species specific action of tested substances. Application of glycoalkaloids on the continuously perfused Z. atratus heart inhibited progressively frequency contractions; higher concentrations exerted short and reversible cardiac arrests. In the rest two beetle species tested glycoalkaloids caused no cardiotropic effect. In vivo bioassay with 1 day old Z. atratus pupae showed that the extract induces a negative inotropic effect on the heart.

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http://dx.doi.org/10.1007/s00128-009-9921-3DOI Listing

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