Asymmetric reduction of ketimines with trichlorosilane can be catalysed by the Lewis-basic N-methylvaline-derived formamide anchored to a soluble dendron () with good enantioselectivity (=94% ee) and low catalyst loading (typically 5 mol%) at room temperature in toluene. This protocol represents an improvement and simplification of the isolation procedure and recovery of the catalyst.
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http://dx.doi.org/10.1039/b916601g | DOI Listing |
Nat Commun
January 2025
Department of Chemical and Petroleum Engineering, University of Calgary, 2500 University Drive, NW, Calgary, AB, Canada.
Solar-driven CO reduction to value-added C chemicals is thermodynamically challenging due to multiple complicated steps. The design of active sites and structures for photocatalysts is necessary to improve solar energy efficiency. In this work, atomically dispersed Ru-O sites in RuInO are constructed by interior lattice anchoring of Ru.
View Article and Find Full Text PDFAngew Chem Int Ed Engl
January 2025
Hunan University, College of Materials Science and Engineering, South Lushan Road 2#, 410082, China, 410082, Changsha, CHINA.
Renewable electricity-driven electrochemical reduction of CO2 offers a promising route for production of high-value ethanol. However, the current state of this technology is hindered by low selectivity and productivity, primarily due to limited understanding of the atomic-level active sites involved in ethanol formation. Herein, we identify that the interfacial oxygen vacancy-neighboring Cu (Ov-Cu) pair sites are the active sites for CO2 electroreduction to ethanol.
View Article and Find Full Text PDFAngew Chem Int Ed Engl
January 2025
Changchun Institute of Applied Chemistry Chinese Academy of Sciences: Chang Chun Institute of Applied Chemistry Chinese Academy of Sciences, Jilin Province Key Lab of Green Chemistry and Process, CHINA.
A modular approach was developed for the first catalytic asymmetric total syntheses of naturally occurring C30 terpene quinone methides and their non-natural stereoisomers, which feature the presence of an unprecedented spiro[4.4]nonane-containing 6-6-6-5-5-3 hexacyclic skeleton. Resting on a chiral phosphinamide-catalyzed enantioselective reduction of 2,2-disubstituted cyclohexane-1,3-dione, a concise route for the synthesis of enantioenriched 6-6 bicyclic fragment was developed.
View Article and Find Full Text PDFAngew Chem Int Ed Engl
January 2025
University of Science and Technology of China, National Synchrotron Radiation Laboratory, 42#, South Road of HeZuoHua, 230029, Hefei, CHINA.
Fe-N-C catalysts, with a planar D4h symmetric FeN4 structure, show promising as noble metal-free oxygen reduction reaction catalysts. Nonetheless, the highly symmetric structure restricts the effective manipulation of its geometric and electronic structures, impeding further enhancements in oxygen reduction reaction performance. Here, a high proportion of asymmetric edge-carbon was successfully introduced into Fe-N-C catalysts through morphology engineering, enabling the precise modulation of the FeN4 active site.
View Article and Find Full Text PDFFASEB J
January 2025
Department of Medicine, Rhode Island Hospital and Brown University School of Medicine, Providence, Rhode Island, USA.
Bromodomain-containing protein 4 (BRD4) plays a vital role in fibrosis of various organs. However, the underlying mechanism of BRD4 in renal fibrosis remains unclear. To construct in vitro and in vivo models of renal fibrosis, TCMK-1 cells were subjected to TGF-β1 treatment and mice were subjected to UUO surgery and adenine induction.
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