AI Article Synopsis
- The epididymis and efferent ducts are essential for sperm maturation and storage, reabsorbing key substances from seminiferous tubules.
- Gpr48-null male mice exhibit reproductive issues and infertility due to reduced levels of estrogen receptor alpha (ERalpha) in these structures.
- The study suggests that Gpr48 activates the cAMP/PKA signaling pathway to upregulate ERalpha expression, impacting the development of the male reproductive system.
Article Abstract
The epididymis and efferent ducts play major roles in sperm maturation, transport, concentration and storage by reabsorbing water, ions and proteins produced from seminiferous tubules. Gpr48-null male mice demonstrate reproductive tract defects and infertility. In the present study, we found that estrogen receptor alpha (ERalpha) was dramatically reduced in the epididymis and efferent ducts in Gpr48-null male mice. We further revealed that ERalpha could be upregulated by Gpr48 activation via the cAMP/PKA signaling pathway. Moreover, we identified a cAMP responsive element (Cre) motif located at -1307 to -1300 bp in the ERalpha promoter that is able to interact with Cre binding protein (Creb). In conclusion, Gpr48 participates in the development of the male epididymis and efferent ducts through regulation of ERalpha expression via the cAMP/PKA signaling pathway.
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| http://dx.doi.org/10.1242/dev.040659 | DOI Listing |
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