AI Article Synopsis
- Tumors and their hosts show changes in circadian rhythms that can help in cancer diagnosis and prognosis.
- The study investigates how melatonin affects circadian rhythms of antioxidants and lipid peroxides in rats with liver cancer induced by a chemical called NDEA.
- Results showed that melatonin improved antioxidant levels and adjusted the disrupted circadian rhythms in treated rats, suggesting it may help prevent cancer through its antioxidant properties and influence on circadian patterns.
Article Abstract
ABSTRACT Tumors and tumor-bearing hosts exhibit markedly altered circadian rhythms, which serve as markers in the early diagnosis and prognosis of cancer. Our study presents the effect of melatonin on circadian rhythms of lipid peroxides and antioxidants in N-nitrosodiethylamine (NDEA)-induced hepatocarcinogenesis. The circadian rhythm characteristics (acrophase, amplitude, and mesor) of thiobarbituric acid reactive substances (TBARS), superoxide dismutase (SOD), catalase (CAT), glutathione peroxidase (GPx), and reduced glutathione (GSH) were markedly altered in NDEA-treated rats. Melatonin administration caused a significant increase in the amplitude and mesor values of antioxidants and a significant decrease in the mesor values of TBARS. Further delays in acrophase in NDEA-treated rats were reversed by melatonin administration. In conclusion, melatonin may exert its chemopreventive effect by its role as an antioxidant as well as by altering the circadian rhythm characteristics.
Download full-text PDF |
Source |
|---|---|
| http://dx.doi.org/10.1080/15376520500195798 | DOI Listing |
Publication Analysis
Top Keywords
Similar Publications
Gender and activity disparities in the relationship between circadian syndrome and gallstone disease.
Front Endocrinol (Lausanne)
January 2025
Department of Gastroenterology, Tianjin University of Traditional Chinese Medicine Second Affiliated Hospital, Tianjin, China.
Objective: To explore the potential correlation between gallstone disease (GSD) prevalence and circadian syndrome (CircS).
Methods: The cross-sectional research utilized data spanning 2017 to March 2020, sourced from the National Health and Nutrition Examination Survey (NHANES). The GSD data were collected via questionnaires, with appropriate sample weights applied to ensure the study population was representative.
Association between night eating frequency and thyroid function and sensitivity: a cross-sectional study from the NHANES database.
Front Endocrinol (Lausanne)
January 2025
Department of Gastrointestinal Surgery, General Surgery, Xichang People's Hospital, Xichang, China.
Thyroid function is closely linked to circadian rhythms, but the relationship between the frequency of night eating and thyroid function remains unclear. Our study aimed to investigate the association between night eating frequency and its impact on thyroid function and sensitivity. This study included 6093 participants from the U.
View Article and Find Full Text PDFPlasticity of enteric neurotransmission varies during day-night cycles and with feeding state.
Am J Physiol Gastrointest Liver Physiol
January 2025
Department of Anatomy and Physiology, theUniversity of Melbourne, Australia.
The circadian cycle is a fundamental biological rhythm that governs many physiological functions across nearly all living organisms. In the gastrointestinal tract, activities such as gut motility, hormone synthesis, and communication between the gut, central nervous system and microbiome all fluctuate in alignment with the circadian cycle. The enteric nervous system (ENS) is critical for co-ordinating many of these activities, however, how its activity is governed by the circadian cycle remains unknown.
View Article and Find Full Text PDFAcute and Lifelong Endurance Exercise Yields Differential Effects During Circadian Disruption in Mice.
Med Sci Sports Exerc
January 2025
Department of Zoology and Physiology, Program in Neuroscience, University of Wyoming, Laramie, WY.
Introduction: Circadian rhythms are responsible for physiological and behavioral processes coordinated in a 24-hour cycle. We investigated whether untimed, long-term voluntary wheel access mitigated circadian disruption and facilitated re-entrainment. Methods: Thirty-four C57Bl/6 J mice (n = 21 males, n = 14 females) were used in this experiment.
View Article and Find Full Text PDFBMAL1 ameliorates type 2 diabetes-induced cognitive impairment via AREG upregulation and PI3K/Akt/GSK-3β pathway activation.
Cell Commun Signal
January 2025
Department of Endocrinology, Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, Hubei, 430030, China.
Cognitive impairment is a significant complication of type 2 diabetes mellitus (T2DM). However, the mechanisms underlying the development of cognitive dysfunction in individuals with T2DM remain elusive. Herein, we discussed the role of Bmal1, a core circadian rhythm-regulating gene, in the process of T2DM-associated cognitive dysfunction.
View Article and Find Full Text PDFWant AI Summaries of new PubMed Abstracts delivered to your In-box?
Enter search terms and have AI summaries delivered each week - change queries or unsubscribe any time!