AI Article Synopsis
- YIGSR peptide anchored sterically stabilized liposomes (YIGSR-SL) show enhanced binding to endothelial cells overexpressing laminin receptors compared to non-targeted liposomes, making them promising carriers for delivering drugs directly to tumors.
- In tests, YIGSR-SL significantly reduced lung metastasis and angiogenesis, proving more effective in tumor regression than free 5-fluorouracil (5-FU) and standard liposomes.
- Overall, the results suggest that YIGSR-SL loaded with 5-FU could be a highly effective targeted therapy for cancer treatment.
Article Abstract
YIGSR peptide anchored sterically stabilized liposomes (YIGSR-SL) were investigated for selective and preferential presentation of carrier contents at angiogenic endothelial cells overexpressing laminin receptors on and around tumor tissue and thus for assessing their targetabilty. In vitro endothelial cell binding of liposomes exhibited 7-fold higher binding of YIGSR-SL to HUVEC in comparison to the nontargeted sterically stabilized liposomes (SL). Spontaneous lung metastasis and angiogenesis assays show that YIGSR peptide anchored liposomes are significantly (P
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http://dx.doi.org/10.3109/10611860903483388 DOI Listing Publication Analysis
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