AI Article Synopsis
- Patients with cervical or mediastinal Hodgkin disease traditionally received chemotherapy along with extended-field radiation therapy.
- Six patients developed significant muscle atrophy and weakness in the neck and shoulder areas 5 to 30 years after receiving mantle irradiation for Hodgkin disease.
- Despite similar clinical symptoms, the underlying causes of muscle issues varied among patients, indicating that both nerve and muscle-related factors may contribute to these complications.
Article Abstract
Patients with cervical or mediastinal Hodgkin disease (HD) classically underwent chemotherapy plus extended-field radiation therapy. We report six patients who gradually developed severe atrophy and weakness of cervical paraspinal and shoulder girdle muscles 5-30 years after mantle irradiation for HD. Although clinical presentation was uniform, including a dropped head syndrome, electrophysiological and pathological findings were rather heterogeneous. Either neurogenic or myogenic processes may be involved and sometimes combined. We discuss the pathophysiological mechanisms underlying these cervicoscapular motor complications of mantle irradiation in HD.
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| http://dx.doi.org/10.1136/jnnp.2008.167577 | DOI Listing |
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