This article describes the use of two treatment tools, time lines and life lines, designed to be used with adults who have had lifelong experience with severe and persistent mental illness. The premise of work with these clients is that their developmental stages and tasks have been skewed by years of mental illness. By graphically charting their reminiscence of life events, many clients can be helped to integrate into society and to resolve negative life experiences. Examples are given for the use of these tools with clients and with family members.
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http://dx.doi.org/10.1093/hsw/16.1.27 | DOI Listing |
Sci Adv
January 2025
Department of Chemical Engineering, University of Michigan, Ann Arbor, MI 48109, USA.
Particle elasticity has widely been established to substantially influence immune cell clearance and circulation time of vascular-targeted carriers (VTCs). However, prior studies have primarily investigated interactions with macrophages, monocytic cell lines, and in vivo murine models. Interactions between particles and human neutrophils remain largely unexplored, although they represent a critical aspect of VTC performance.
View Article and Find Full Text PDFJ Neurooncol
January 2025
National Clinical Research Center for Ocular Diseases, Eye Hospital, Wenzhou Medical University, Wenzhou, 325027, China.
Purpose: This study explores the effects of mifepristone on the proliferation, motility, and invasion of malignant and benign meningioma cells, aiming to identify mifepristone-sensitive types and investigate the underlying molecular mechanisms.
Methods: IOMM-Lee and HBL-52 meningioma cells were treated with 0, vehicle control (VC), 5, 10, 20, 40, and 80 μM of mifepristone for 12, 24, 48, 72, and 96 h. Proliferation was assessed via CCK8 assay, while motility and invasion were measured using wound scratch and transwell assays.
Alzheimers Dement
December 2024
UK Dementia Research Institute at Cardiff University, Cardiff, South Glamorgan, United Kingdom.
Background: Genome-wide association studies (GWAS) in Alzheimer's disease (AD) implicate complement in pathogenesis. Complement receptor 1 (CR1; CD35) is a top AD-associated GWAS hit; the long variant, CR1*2, associates with risk. The roles of CR1 in brain and how variants influence AD risk are poorly understood.
View Article and Find Full Text PDFAlzheimers Dement
December 2024
University of Washington, Seattle, WA, USA.
Background: Anticholinergic (AC) use remains common in older adults despite evidence of safety risks, including dementia risk. Evidence from population studies suggests that dementia risk may vary by AC class. This variation might be explained by confounding by indication.
View Article and Find Full Text PDFAlzheimers Dement
December 2024
McLaughlin Research Institute, Great Falls, MT, USA.
Background: Apolipoprotein E (ApoE) is a lipid cargo binding protein that has three variants in humans, ApoE 2, 3, and 4. The ApoE 4 allele is the greatest known genetic factor for sporadic Alzheimer's Disease. The gut microbiome (GMB) is a key essential to health, and bacterial dysbiosis can lead to poorer outcomes for disease states and an increase in microbiota and their metabolites in the peripheral.
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