AI Article Synopsis
- Researchers discovered they could temporarily disrupt the blood-brain barrier (BBB) using low-frequency ultrasonic waves (28 kHz) with microbubbles, rather than high-frequency methods.
- This method allowed for a controlled application of ultrasound and created extensive BBB disruption over areas typical of brain tumors.
- The approach offers benefits like better portability, larger treatment areas, fewer bleeding complications, and less reliance on imaging for treating superficial brain issues.
Article Abstract
Disruption of the blood-brain barrier (BBB) may be transiently achieved via high-frequency focused spherical ultrasound in the presence of microbubbles. In this experimental animal study, we sought to determine whether focal reversible opening of the BBB may be achieved using low-frequency (i.e., 20-30 kHz) planar ultrasonic waves. In the presence of microbubbles, we were able to obtain BBB opening using non-focused ultrasound irradiation with a frequency as low as 28 kHz. We also achieved a tight regulation of the ultrasound patterns by using a mechanical scanning device equipped with a pinhole. Histologic examination of the brains supported the feasibility of our system. The areas of BBB disruption obtained with this method were large enough to cover a typical circumscribed cerebral tumor mass. The inherent advantages of our BBB opening method include an improved portability, the possibility to obtain fairly wide areas of BBB opening and a low incidence of hemorrhagic complications. In addition, our system has the potential to reduce the need for image guidance for treating superficial brain lesions.
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| http://dx.doi.org/10.1016/j.ultrasmedbio.2009.10.004 | DOI Listing |
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