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Supplementation of 3'-Sialyllactose During the Growth Period Improves Learning and Memory Development in Mice.
J Agric Food Chem
November 2024
State Key Laboratory of Food Science and Resources, Nanchang University, Nanchang 330047, China.
Article Synopsis
- 3'-Sialyllactose (3'-SL), a key component found in human milk, was given to 3-week-old C57BL/6 mice for 6 weeks to study its effects on cognitive development and memory.
- The study showed significant improvements in cognitive abilities and memory in the mice, linked to an increase in specific genes in their hippocampal tissue related to learning.
- Furthermore, 3'-SL altered the mice's gut microbiota, which, in combination with enzyme activity, enhanced the availability of sialic acid, supporting brain development and indicating potential pathways for cognition enhancement.
The Impact of FGFR3 Alterations on the Tumor Microenvironment and the Efficacy of Immune Checkpoint Inhibitors in Bladder Cancer.
Mol Cancer
November 2023
Department of Urology, Osaka Medical and Pharmaceutical University, 2-7 Daigaku-Machi, Takatsuki City, Osaka, 569-8686, Japan.
Article Synopsis
- There is currently limited understanding of how alterations in fibroblast growth factor receptor 3 (FGFR3) affect bladder cancer (BLCA) and its tumor microenvironment (TME).
- A study involving multi-omics analysis of BLCA tissues showed that aFGFR3 alterations are found in 44% of non-muscle invasive cases and 15% of muscle-invasive cases, affecting their immune response and tumor characteristics.
- Notably, the LumP subtype in aFGFR3 cases responded significantly better to checkpoint inhibitors compared to their intact FGFR3 counterparts, suggesting that FGFR3 status influences treatment outcomes in bladder cancer.
Surfaceome Profiling of Cell Lines and Patient-Derived Xenografts Confirm FGFR4, NCAM1, CD276, and Highlight AGRL2, JAM3, and L1CAM as Surface Targets for Rhabdomyosarcoma.
Int J Mol Sci
January 2023
Department of Pediatric Hematology and Oncology, Inselspital, Bern University Hospital, University of Bern, 3010 Bern, Switzerland.
Rhabdomyosarcoma (RMS) is the most common soft tissue sarcoma in children. The prognosis for patients with high-grade and metastatic disease is still very poor, and survivors are burdened with long-lasting side effects. Therefore, more effective and less toxic therapies are needed.
View Article and Find Full Text PDFMeta-analysis of transcriptomics data identifies potential biomarkers and their associated regulatory networks in gallbladder cancer.
Gastroenterol Hepatol Bed Bench
January 2022
Department of Biotechnology, Gauhati University, Guwahati, Assam, India.
Aim: This study aimed to identify key genes, non-coding RNAs, and their possible regulatory interactions during gallbladder cancer (GBC).
Background: The early detection of GBC, i.e.
Prenatal glucocorticoid exposure selectively impairs neuroligin 1-dependent neurogenesis by suppressing astrocytic FGF2-neuronal FGFR1 axis.
Cell Mol Life Sci
May 2022
Department of Veterinary Physiology, College of Veterinary Medicine, Research Institute for Veterinary Science, and BK21 Four Future Veterinary Medicine Leading Education and Research Center, Seoul National University, Seoul, 08826, Korea.
Exposure to maternal stress irreversibly impairs neurogenesis of offspring by inducing life-long effects on interaction between neurons and glia under raging differentiation process, culminating in cognitive and neuropsychiatric abnormalities in adulthood. We identified that prenatal exposure to stress-responsive hormone glucocorticoid impaired neurogenesis and induced abnormal behaviors in ICR mice. Then, we used human induced pluripotent stem cell (iPSC)-derived neural stem cell (NSC) to investigate how neurogenesis deficits occur.
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