AI Article Synopsis
- Nanotechnology is increasingly utilized in various fields like industry, biology, and medicine, highlighting its potential benefits.
- However, concerns about the toxicity of nanosized products, particularly regarding their effects on the immune system, remain significant.
- The review discusses how engineered nanoparticles can either evade immune detection or manipulate immune responses, examining theories on how altering their properties can achieve targeted immune modulation while minimizing toxicity.
Article Abstract
Today nanotechnology is finding growing applications in industry, biology, and medicine. The clear benefits of using nanosized products in various biological and medical applications are often challenged by concerns about the lack of adequate data regarding their toxicity. One area of interest involves the interactions between nanoparticles and the components of the immune system. Nanoparticles can be engineered to either avoid immune system recognition or specifically inhibit or enhance the immune responses. We review herein reported observations on nanoparticle-mediated immunostimulation and immunosuppression, focusing on possible theories regarding how manipulation of particle physicochemical properties can influence their interaction with immune cells to attain desirable immunomodulation and avoid undesirable immunotoxicity.
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| http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2817614 | PMC |
| http://dx.doi.org/10.1210/en.2009-1082 | DOI Listing |
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