Direct arylations of 2H-indazoles on water.

Org Lett

University of Edinburgh, School of Chemistry, Joseph Black Building, King's Buildings, West Mains Rd., Edinburgh EH9 3JJ, UK.

Published: January 2010

AI Article Synopsis

  • The study presents a method for synthesizing various 2H-Indazoles using palladium as a catalyst.
  • The reactions take place in water, which makes the process more efficient and environmentally friendly.
  • This approach allows for the easy creation of 2,3-diaryl indazoles, compounds that are important in many biological applications.

Article Abstract

The efficient palladium-catalyzed synthesis of a range of substituted 2H-Indazoles via C-H arylation is reported. Reactions are performed on water and provide a direct and mild route toward 2,3-diaryl indazoles of widespread biological significance.

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http://dx.doi.org/10.1021/ol902537dDOI Listing

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