Total syntheses of the Lycopodium alkaloids nankakurines A and B have been accomplished in 6 and 7 steps, respectively, via a sequence that passes through a third Lycopodium alkaloid, luciduline, and forgoes the use of protecting groups on nitrogen. Key features include a short preparation of luciduline followed by a concise and stereoselective aminoallylation/ring-closing metathesis protocol to fashion the spiropiperidine ring common to nankakurines A and B.
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| http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2804776 | PMC |
| http://dx.doi.org/10.1021/ol902455y | DOI Listing |
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